Egilok, tablets 50 mg 60 pcs

Indications

– Arterial hypertension (in monotherapy or in combination with other antihypertensive drugs);
– Chronic heart failure in the compensation stage (in addition to standard therapy with diuretics, ACE inhibitors, cardiac glycosides);
– CHD (secondary prevention of myocardial infarction, prevention of angina attacks);
– hyperkinetic cardiac syndrome;
– hyperthyroidism (as a part of complex therapy);
– prevention of migraine attacks.

Active ingredient

Composition

1 tablet contains metoprolol tartrate 50 mg;

auxiliary substances:

MCC;

Sodium carboxymethyl starch;

Colloidal anhydrous silica;

povidone;

magnesium stearate.

How to take, the dosage

Egilok is prescribed for arterial hypertension in a daily dose of 50-100 mg/day in 1 or 2 doses. In case of insufficient therapeutic effect, the daily dose may be gradually increased to 100-200 mg.

In angina pectoris, supraventricular arrhythmias, for prevention of migraine attacks, the dose of 100-200 mg/day in 2 doses (morning and evening) is prescribed.

For secondary prevention of myocardial infarction, an average daily dose of 200 mg in 2 doses (morning and evening) is prescribed.

In functional disorders of cardiac activity accompanied by tachycardia, a daily dose of 100 mg in 2 doses (morning and evening) is prescribed.

The tablets should be taken orally with or immediately after a meal. The tablets may be divided in half, but not chewed.

Interaction

When concomitant use of Egilok with MAO inhibitors, a significant increase in the hypotensive effect is possible. A break between taking MAO inhibitors and Egilok should be at least 14 days.

Concomitant intravenous administration of verapamil may provoke cardiac arrest, concomitant administration of nifedipine leads to a significant decrease in BP.

The agents for inhalation anesthesia (hydrocarbon derivatives) when used concomitantly with Egiloc increase the risk of inhibition of myocardial contractile function and development of arterial hypotension.

When used concomitantly, beta-adrenergic stimulants, theophylline, cocaine, estrogens, indomethacin and other NSAIDs reduce the hypotensive effect of Egiloc.

When concomitant use of Egilok and ethanol an increase in CNS depressant effect is noted.

Concomitant use of Egilok with ergot alkaloids increases the risk of peripheral circulatory disorders.

Concomitant use of Egilok increases the effect of oral hypoglycemic drugs and insulin and increases the risk of hypoglycemia.

Concomitant use of Egilok with antihypertensives, diuretics, nitrates, calcium channel blockers increases the risk of arterial hypotension.

In concomitant use of Egilok with verapamil, diltiazem, antiarrhythmic agents (amiodarone), reserpine, methyldopa, clonidine, guanfacine, agents for general anesthesia and cardiac glycosides may increase the severity of HR depression and suppression of AV conduction.

Hepatic microsomal enzyme inducers (rifampicin, barbiturates) increase metabolism of metoprolol, which leads to decreased plasma concentrations of metoprolol and decreased effect of Egilok.

Hepatic microsomal enzyme inhibitors (cimetidine, oral contraceptives, phenothiazines) increase the plasma concentration of metoprolol.

Allergens used for immunotherapy or allergen extracts for skin tests, when combined with Egiloc, increase the risk of systemic allergic reactions or anaphylaxis.

Iodine-containing x-ray contrast agents for IV administration increase the risk of anaphylactic reactions when used concomitantly with Egiloc.

Egilok with concomitant use decreases clearance of xanthines, especially in patients with initially increased clearance of theophylline due to smoking.

Concomitant use with Egiloc decreases lidocaine clearance and increases plasma lidocaine concentrations.

Concomitant use of Egilok increases and prolongs the effect of nondepolarizing muscle relaxants; prolongs the effect of indirect anticoagulants.

Concomitant use with ethanol increases the risk of significant BP decrease.

Special Instructions

The heart rate and BP should be monitored regularly when prescribing Egilok. The patient should be warned that if the HR is less than 50 bpm, a physician should be consulted.

In patients with diabetes mellitus, blood glucose levels should be monitored regularly and the dose of insulin or oral hypoglycemic drugs should be adjusted if necessary.

Prescribing Egilok to patients with chronic heart failure is possible only after reaching the stage of compensation.

Patients taking Egilok may have increased hypersensitivity reactions (with a history of allergy) and have no effect after administration of usual doses of epinephrine (adrenaline).

The use of Egilok may aggravate the symptoms of peripheral circulatory disorders.

Egiloc should be withdrawn gradually, gradually reducing the dose over 10 days. Withdrawal syndrome (worsening of angina attacks, increase of BP) may occur if treatment is stopped abruptly. During drug withdrawal, patients with angina pectoris should be under close medical supervision.

In angina patients with tension angina, the selected dose of the drug should provide an HR at rest within 55-60 beats/min, and not more than 110 beats/min on exertion.

Patients who wear contact lenses should be aware that treatment with beta-adrenoblockers may decrease lacrimal fluid production.

Methoprolol may mask some clinical manifestations of hyperthyroidism (tachycardia). Abrupt withdrawal in patients with thyrotoxicosis is contraindicated because it may exacerbate the symptoms.

In diabetics taking Egilok may mask the symptoms of hypoglycemia (tachycardia, sweating, increased BP).
When metoprolol is administered to patients with bronchial asthma, beta2-adrenomimetics should be used concomitantly.
In patients with pheochromocytoma, Egilok should be used in combination with alpha-adrenoblockers.

Before any surgical intervention, the anesthesiologist should be informed about the therapy with Egilok (choice of general anesthesia drug with minimal negative inotropic effect); cancellation of the drug is not required.

When prescribing the drug in elderly patients, hepatic function should be monitored regularly. Correction of the dosage regimen is required only in case of increasing bradycardia, marked BP decrease, AV-blockade, bronchospasm, ventricular arrhythmias, severe liver function abnormalities in elderly patients. Sometimes it is necessary to stop treatment.

Patients with a history of depressive disorders should be especially monitored. If depression develops, Egiloc should be discontinued.

Pediatric use

The efficacy and safety of Egiloc in children and adolescents under 18 years of age have not been determined.

Impact on driving and operating ability

In patients whose activities require increased attention, the outpatient administration of the drug should be decided only after evaluating the patient’s individual response.

Contraindications

– Cardiogenic shock;
– II and III degree AV-blockade;
– sinoatrial block;
– CCSU;
– expressed bradycardia (heart rate less than 50 beats/min).
– heart failure in decompensation stage;
– angiospastic angina pectoris (Prinzmetal angina pectoris);
– significant arterial hypotension (systolic BP below 100 mm Hg.Lactation period;
– concurrent use of MAO inhibitors;
– concurrent intravenous administration of verapamil;
– hypersensitivity to metoprolol and other ingredients of the preparation.

. The preparation should be used with caution in diabetes mellitus, metabolic acidosis, bronchial asthma, chronic obstructive pulmonary disease (pulmonary emphysema, chronic obstructive bronchitis), peripheral vascular obliterating diseases (intermittent claudication, Raynaud’s syndrome), liver failure, chronic renal failure, myasthenia gravis, pheochromocytoma, 1st degree AV-blockade, thyrotoxicosis, depression (including anamnesis).including in anamnesis), psoriasis, as well as in children and adolescents under 18 years old and elderly patients.

Side effects

CNS and peripheral nervous system: increased fatigue, weakness, headache, slowed rate of mental and motor reactions; rarely – paresthesias in the extremities, depression, anxiety, decreased ability to concentrate, drowsiness, insomnia, nightmares, confusion or short-term memory loss, asthenic syndrome, muscle weakness.

Sensory organs: rarely – decreased vision, decreased tear fluid secretion, xerophthalmus, conjunctivitis, tinnitus.

Cardiovascular system disorders: Sinus bradycardia, palpitations, decreased BP, orthostatic hypotension; rarely – reduced myocardial contractility, temporary aggravation of symptoms of chronic heart failure, arrhythmias, increased peripheral circulation disorders (coldness of the lower extremities, Raynaud syndrome), myocardial conduction disorders; in isolated cases – AV-blockade, cardialgia.

Digestive system disorders: nausea, vomiting, abdominal pain, diarrhea, constipation, dry mouth, change in taste; increased activity of liver transaminases; rarely – hyperbilirubinemia.

Dermatological reactions: urticaria, skin itching, rash, exacerbation of psoriasis, psoriasis-like skin changes, skin hyperemia, exanthema, photodermatosis, increased sweating, reversible alopecia.

Respiratory system: nasal congestion, difficulty in exhaling (bronchospasm in high doses or in susceptible patients), shortness of breath.

Endocrine system disorders: hypoglycemia (in patients receiving insulin); rarely – hyperglycemia.

Hematopoietic system: thrombocytopenia, agranulocytosis, leukopenia.

Others: back or joint pain, slight increase in body weight, decreased libido and/or potency.

Overdose

Symptoms: pronounced sinus bradycardia, dizziness, nausea, vomiting, cyanosis, arterial hypotension, arrhythmia, ventricular extrasystole, bronchospasm, syncope; in acute overdose – cardiogenic shock, loss of consciousness, coma, AV-blockade up to development of complete transverse block and cardiac arrest, cardialgia.

The first signs of overdose appear 20 minutes to 2 hours after intake.

Treatment: gastric lavage, prescription of adsorbents, symptomatic therapy: in case of pronounced BP decrease – Trendelenburg position, in case of acute arterial hypotension, bradycardia and threatening heart failure – intravenous (at 2-5 min intervals) injection of beta-adrenostimulants or intravenous injection of 0.5-2 mg of atropine sulfate, in the absence of a positive effect – dopamine, dobutamine or norepinephrine.

As a follow-up, 1-10 mg of glucagon may be administered, and a transvenous intracardiac pacemaker may be placed. In bronchospasm – IV administration of beta2-adrenergic stimulants, in seizures – slow IV administration of diazepam. Metoprolol is poorly excreted by hemodialysis.

Similarities