Dusopharm, 50 mg 90 pcs.

Duzofarm has a vasodilator effect, as a result of which it improves peripheral and cerebral blood flow. It causes reduction of peripheral vascular resistance and increases cardiac output without significant effect on heart rate and blood pressure. < br>

The vasodilatory effect of Dusofarm results from its direct myotropic, antagonistic to serotonin 5NT2 receptors and alpha-adrenoblocking action. < br>

It has an M-choline-blocking effect. < br> < br> < br> It has a positive effect on cellular metabolism, improving oxygen and glucose utilization. This effect of the drug is due to its ability to increase the level of ATP and inhibit the enzyme succinate dehydrogenase. < br>

Activates the utilization of glucose through the citric acid cycle and increases the conversion of succinic acid to fumaric acid. As a result, it increases the resistance of cells (including the brain) to hypoxia. In addition, Dusofarm reduces increased blood viscosity.

Indications

Restorative period of cerebral circulatory disorders; peripheral circulatory disorders (intermittent claudication, Raynaud’s disease, trophic ulcers).

Active ingredient

Composition

1 tablet contains:

Active substance:

naphthidrofuryl oxalate – 50 mg.

Auxiliary substances:

lactose monohydrate;

microcrystalline cellulose;

wheat starch;

copovidone;

colloidal silicon dioxide;

magnesium stearate;

talc.

Covering composition:

Titanium dioxide; talc; magnesium stearate; macrogol 6000; methacrylic acid and ethyl acrylate copolymer; sunset yellow dye E110.

How to take, the dosage

Ingestion. Tablets are taken whole, with enough liquid (it is recommended to drink water).

In case of cerebral circulatory disorders: in a daily dose of 300 mg (2 tablets 3 times a day).

In peripheral circulatory disorders: daily doses of 500-600 mg divided into 3 doses.

Duzofarm is recommended for long-term oral therapy (up to 6 months).

Dose adjustment in renal/hepatic insufficiency is not required.

.

Interaction

It enhances the hypotensive effect of antihypertensive drugs.

In this regard, more frequent monitoring of blood pressure at the beginning of combined treatment with Dusopharm and antihypertensive drugs simultaneously is recommended.

Contraindications

Individual hypersensitivity to the drug. Myocardial infarction (acute stage).

Arterial hypotension. Hemorrhagic stroke (acute stage).

Epilepsy, increased seizure readiness.

Chronic heart failure stages II-III (III-IV according to NYHA – New York Heart Association functional classification of heart failure).

Tachyarrhythmia. Age under 18 years (efficacy and safety not established).

With caution: closed-angle glaucoma; prostatic hyperplasia.

Side effects

When taken orally in doses of 300 to 600 mg Dusofarm is well tolerated in general.

Possible side effects: nausea, vomiting, epigastric pain, intestinal colic, diarrhea, decreased appetite, headache, dizziness, sleep disturbance, reversible increase in liver enzyme activity, gastric mucosa ulcers, allergic reactions.

Overdose

Symptoms: increased severity of side effects, ventricular arrhythmia, anxiety, decreased blood pressure, bradycardia.

Treatment: gastric lavage, administration of activated charcoal and laxatives, symptomatic treatment.

There is no specific antidote.