Doxylamine-SZ, 15 mg 30 pcs.

H1-histamine receptor antagonist.

ATX code:

R06AA09.

Pharmacological properties

Pharmacodynamics

A H1-histamine receptor blocker from the group of ethanolamines. It has soporific, sedative and M-cholinoblocking effects. It shortens the time to fall asleep, increases the duration and quality of sleep, and does not change the phase of sleep. The duration of action is 6-8 hours.

Pharmacokinetics

The maximum plasma concentration (Cmax) is reached on average 2 hours after oral administration. The half-life of doxylamine (T1/2) is about 10 hours.

The absorption is high, metabolized in the liver. It penetrates well through histohematic barriers, including the blood-brain barrier.
It is excreted 60% by the kidneys unchanged, partially through the gastrointestinal tract (GIT).

Pharmacokinetics of the drug in special groups of patients

In patients older than 65 years old and in patients with hepatic and renal insufficiency half-life can be prolonged. When repeated courses of treatment, stable plasma concentrations of the drug and its metabolites are reached later and at higher levels.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

It should be taken into account that insomnia can be caused by a number of reasons in which it is not necessary to prescribe this medication.

The drug Doxylamine-SZ has a sedative effect, suppresses cognitive abilities and slows psychomotor reactions. First generation H1-antihistamine drugs may have m-cholinoblocking, anti-alpha-adrenergic and antiserotonin effects, which may cause dry mouth, constipation, urinary retention, accommodation and visual disturbances.

Like all sleeping pills or sedatives, doxylamine can aggravate nocturnal apnea syndrome (sudden respiratory arrest in sleep) by increasing the number and duration of apnea attacks.

The drug contains 98.2 mg of lactose monohydrate per tablet, which should be considered in patients with rare congenital galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.

With regard to possible drowsiness during the daytime, driving, operating machinery, and other activities requiring increased concentration and rapid psychomotor reactions should be avoided.

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

Similarities