Doxi-Hem, 500 mg capsules 90 pcs

Pharmacodynamics

Angioprotector, reduces increased vascular permeability, increases the resistance of capillary walls, improves microcirculation and drainage function of lymph vessels, moderately reduces platelet aggregation and blood viscosity, increases the elasticity of red blood cell membrane.

Action is associated, to some extent, with an increase in plasma kininin activity.

Pharmacokinetics

Rapidly absorbed in the gastrointestinal tract.

Maximal concentration in plasma is reached 6 hours after oral administration.

Binding to plasma proteins is 20-25 %. It practically does not pass through the blood-brain barrier.

It is excreted by the kidneys (about 50%) and through the intestines (about 50%), mainly unchanged within 24 hours, 10% – as metabolites. Half-life period is 5 hours.

Very small amounts (0.4 mcg/ml after taking 1.5 g of the drug) are excreted with breast milk.

Indications

Vascular lesions with increased capillary fragility and permeability (diabetic retinopathy and nephropathy) and other microangiopathies associated with various cardiovascular and metabolic diseases.

Venous insufficiency of varying degrees of severity and its consequences (preeclampsia with signs of tissue edema, pain, paresthesias, congestive dermatosis; surface phlebitis, varicose veins, trophic ulcers).

Active ingredient

Composition

How to take, the dosage

Interaction

Directions for use

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Pregnancy use