Doverin, 40 mg tablets 48 pcs

Pharmacodynamics:

Myotropic antispasmodic, isoquinoline derivative. It inhibits phosphodiesterase IV, which leads to accumulation of intracellular cyclic adenosine monophosphate and as a consequence to inactivation of myosin light chain kinase, resulting in relaxation of smooth muscles.

Independent on the type of autonomic innervation, drotaverine acts on smooth muscles in the gastrointestinal tract, biliary, urogenital and vascular systems. In the myocardium and vessels, the enzyme that hydrolyzes cyclic adenosine monophosphate is phosphodiesterase III, which explains the absence of serious cardiovascular side effects and the low therapeutic effect on the cardiovascular system.

Pharmacokinetics:

It is rapidly and completely absorbed in the gastrointestinal tract. Bioavailability when administered orally is close to 100%, half-absorption period is 12 min. It is evenly distributed in the tissues, penetrates into the smooth muscle cells. It is mainly excreted by kidneys, to a lesser extent – with bile. It does not penetrate through the blood-brain barrier.

Indications

– Smooth muscle spasms associated with diseases of the biliary tract (cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, papillitis);

– spasms of the smooth muscles of the urinary tract (nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesm).

As adjunctive therapy:

– in spasms of the smooth muscles of the gastrointestinal tract (gastric and duodenal ulcer, gastritis, cardiac and gatekeeper spasms, enteritis, colitis, spastic colitis with constipation and mucous colitis with flatulence);

– tensor headache;

– in gynecological diseases (dysmenorrhea).

Active ingredient

Composition

Active substance:

drotaverine hydrochloride – 40 mg.

Auxiliary substances:

lactose monohydrate (milk sugar) – 63 mg,

potato starch – 32 mg,

How to take, the dosage

Ingestion. Adults, 40-80 mg (1-2 tablets) 2-3 times a day.

Interaction

It enhances the effect of other antispasmodics (including m-cholinoblockers), arterial hypotension caused by tricyclic antidepressants, quinidine, procainamide. Reduces the spasmogenic activity of morphine and the antiparkinsonian properties of levodopa.

The antispasmodic effect of drotaverine is increased with concomitant use with phenobarbital.

Special Instructions

In the treatment of peptic ulcer disease of the stomach and duodenum it is used in combination with other anti-ulcer drugs.

Contraindications

Hypersensitivity to the active substance or any of the ingredients of the drug, severe renal or hepatic failure, severe heart failure (low cardiac output syndrome), lactation, children under 18 years of age. Do not take for people with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

With caution – with arterial hypotension, marked atherosclerosis of the coronary arteries, prostatic hyperplasia, glaucoma, during pregnancy.

Side effects

Gastrointestinal disorders (nausea, constipation), nervous system disorders (headache, dizziness, insomnia); cardiovascular disorders (palpitations, arterial hypotension), allergic reactions (including allergic dermatosis).

Overdose

Atrioventricular block, cardiac arrest, respiratory center paralysis.

Treatment: drug withdrawal, symptomatic therapy. There is no specific antidote.

Similarities