Doritricin, tablets 10 pcs

Doritricin is a complex medication with an effect due to its constituent components.

Benzocaine is a local anesthetic that reduces pain on swallowing, which often accompanies infections and inflammations of the mouth and throat.

Benzalkonium chloride is a quaternary ammonium compound, belongs to cationic surfactants, interacts with lipoproteins and interferes with cell membrane permeability. It has antiseptic properties, is active against Gram-positive bacteria and has fungicidal effect against Candida albicans and some lipophilic viruses.

Tyrotricin is a topical antibiotic, which is a mixture of antimicrobial linear and cyclic polypeptides isolated at the stage of fermentation of Brevibacillus brevis Dudos, consisting mainly of gramicidin and tyrocidin. Tyrotricin acts bactericidally by disrupting phosphorylation processes in the cellular respiration chain and destroying bacterial cell membranes. Because of the special mechanism of action of tyrotricin, which is absent in antibiotics of systemic action, cross-resistance to the drug does not occur.

Pharmacokinetics

Benzocaine is slightly soluble in water, which causes its slow absorption. Like all etheric derivatives of para-aminobenzoic acid it is cleaved with esterase in plasma and liver. As a result, para-aminobenzoic acid and ethyl alcohol are formed, which is metabolized to acetyl coenzyme A.

Para-aminobenzoic acid undergoes conjugation with glycine or is excreted unchanged by the kidneys.

Benzalkonium chloride is practically not absorbed, has no resorptive effect and is excreted by the kidneys. No accumulation of the substance in body tissues has been found.

Tyrotricin – due to low systemic absorption there are no data on pharmacokinetics. Does not affect the intestinal microflora.

Indications

Infectious inflammatory diseases of the mouth and throat, accompanied by pain syndrome:

Composition

Active substances:

benzalkonium chloride 1 mg;

benzocaine 1.5 mg;

tyrotricin 0.5 mg;

Associates:

Sorbitol 871 mg,

Talc 80 mg,

povidone (polyvidone K25) 10 mg,

Sodium carmellose 10 mg,

saccharose stearate 20 mg,

peppermint leaf oil 5 mg,

sodium saccharinate 1 mg.

How to take, the dosage

In the mouth. Adults and children over 6 years of age, slowly suck 1 tablet every 3 hours in the mouth.

The maximum daily dose is 6 tablets.

The course of treatment is 7 days.

Increasing the course of therapy if necessary – on the doctor’s recommendation.

Interaction

No cases of clinically significant interaction of Doritricin with other medicinal products have been described.

Special Instructions

Information for diabetics: 1 tablet of the drug has approximately 0.07 bread units (BE) of carbohydrate.

Impact on the ability to drive vehicles and other mechanisms requiring increased concentration.

Contraindications

Side effects

Allergic reactions, rarely – gastrointestinal disorders (nausea, diarrhea) are possible.

If any of the side effects mentioned in the instructions worsen, or if you notice any other side effects not mentioned in the instructions, tell your doctor.

Overdose

No cases of overdose have been described in the recommended doses.

Accidental administration of high doses of Doritricin may cause digestive system disorders (nausea, vomiting, diarrhea). In this case, it is necessary to flush the stomach, take activated charcoal and consult a doctor.

Pregnancy use

The use of Doritricin during pregnancy and lactation is possible if the expected benefits to the mother exceed the potential risk to the fetus.