Dixin, 10 mg/ml 10 pcs

Pharmacotherapeutic group: antimicrobial agent – quinoxaline.

ATC code: not assigned.

Pharmacological properties

Pharmacodynamics

A broad spectrum antibacterial drug from the group of quinoxaline derivatives. It is active against Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp., Staphylococcus spp., Streptococcus spp., pathogenic anaerobes (Clostridium perfringens). Acts on strains of bacteria resistant to other antimicrobial drugs, including antibiotics.

The development of drug resistance of bacteria is possible. Treatment of burn and purulent-necrotic wounds, promotes faster clearing of the wound surface, stimulates reparative regeneration and marginal epithelization and favorably influences the course of the wound process.

The mechanism of bactericidal action of hydroxymethylquinoxalindioxide is damage of DNA biosynthesis of the microbial cell.

Pharmacokinetics

When applied topically, it is partially absorbed from the wound or burn surface and excreted by the kidneys.

Indications

How to take, the dosage

Special Instructions

The drug is used under close medical supervision in a hospital setting. Hydroxymethylquinoxalindioxide is administered to adults only. Before the start of treatment a test for drug tolerance is carried out, for which 10 ml of 1% solution is injected into the cavity. If there are no side effects (dizziness, chills, increased body temperature) within 3-6 hours, a course of treatment shall be started. Otherwise, the drug is not prescribed.

Hydroxymethylquinoxalindioxide is prescribed only in severe forms of infectious diseases or when other antibacterial agents, including cephalosporins of II-IV generations, fluoroquinolones, carbapenems are ineffective.

In chronic renal failure the dose is reduced.

In case of pigmented spots, increase the duration of the dose to 1.5-2 hours, decrease the dose, prescribe antihistamines, or discontinue hydroxymethylquinoxalindioxide.

To prevent adverse reactions, use in combination with antihistamines and calcium preparations is recommended.

In case of adverse reactions, the dose should be reduced, antihistamines should be prescribed, and the drug should be discontinued if necessary.

When used in elderly people, the age-related reduction in renal function should be taken into account, which may require reducing the dose of the drug.

If crystals precipitate during storage, they are dissolved by heating the ampoules in a boiling water bath while shaking until the crystals are completely dissolved (clear solution). If when cooling to 36-38°C the crystals do not precipitate again, the drug is suitable for use.

The drug should not be used for intravenous administration due to instability of the solution when stored at low temperatures.

When using the drug, caution must be exercised while driving vehicles and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity to hydroxymethylquinoxalindioxide, other drugs of quinoxaline group, adrenal insufficiency (including anamnesis), pregnancy, lactation, childhood (under 18 years).

Renal insufficiency.

Side effects

Overdose

Pregnancy use