Diosmin, 600 mg 30 pcs.

Pharmacodynamics

Diosmin is a benzpyron derivative. It belongs to the group of bioflavonoids. It has phlebotonic action (decreases venous distensibility, increases venous tone (dose-dependent effect), decreases venous congestion), improves lymphatic drainage (increases tone and frequency of contraction of lymph capillaries, increases their functional density, reduces lymphatic pressure), It improves microcirculation (increases capillary resistance (dose-dependent effect), decreases their permeability), reduces leukocyte adhesion to the venous wall and their migration into the paravenous tissue, improves oxygen diffusion and perfusion in the skin tissue, has anti-inflammatory effect.

It enhances vasoconstrictor effect of adrenaline and noradrenaline, blocks production of free radicals, synthesis of prostaglandins and thromboxane. It was shown that diosmin decreases plasma levels of enzymes responsible for metabolism of mucopolysaccharides in the venous wall.

In clinical trials diosmin decreased venous bed capacity and venous stasis volume (according to plethysmography), decreased average pressure in deep and superficial leg veins (according to ultrasound Dopplerography) and increased systolic and diastolic blood pressure in patients with postoperative orthostatic hypotension. Pharmacokinetics Absorption Rapidly absorbed from the gastrointestinal tract, detected in plasma 2 hours after administration. Bioavailability of diosmin after oral administration is approximately 40-57.9%.

Diosmin is transformed by intestinal microflora into diosmetin, hippuric acid and benzoic acid. Distribution Maximum concentration in plasma is reached 5 hours after intake. Diosmin is evenly distributed and accumulated in all layers of the wall of hollow veins and subcutaneous veins of lower limbs, to a lesser extent – in kidneys, liver, lungs and other tissues.

Distribution volume is 62.1 liters. Selective accumulation of diosmin and/or its metabolites in the venous vessels reaches a maximum by the ninth hour after administration and persists for 96 hours. Metabolism Diosmin is metabolized in the liver. The main metabolite is hydroxyphenylpropionic acid.

Metabolites of diosmin are excreted mainly by the kidneys in the form of conjugates with glucuronic acid.

Excretion 79% of ingested diosmin is excreted by kidneys, through the intestine – 11%, in the bile – 2.4%. Enterohepatic circulation of diosmin is observed. After intake of diosmin labeled with a radioactive isotope, about 86% is excreted by the kidneys and intestines within 48 hours.

Indications

Active ingredient

Directions for use

Special Instructions

Contraindications

Side effects

Overdose

Pregnancy use

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