Diltiazem Lannacher, 90 mg 20 pcs

Diltiazem Lannacher is antiarrhythmic, antihypertensive, vasodilator, antianginal.

Blocking calcium channels, reduces the flow of calcium ions into myocardial cells.

Causes dilatation of coronary arteries, thereby increasing coronary blood flow.

Creases tone of smooth muscle of peripheral arteries and RPS.

Indications

arterial hypertension
angina pectoris
supraventricular arrhythmias.

Pharmacological effect

Diltiazem Lannacher – antiarrhythmic, antihypertensive, vasodilator, antianginal.

By blocking calcium channels, it reduces the flow of calcium ions into myocardial cells.

Causes dilation of the coronary arteries, thereby increasing coronary blood flow.

Reduces the tone of smooth muscles of peripheral arteries and peripheral vascular resistance.

Special instructions

Diltiazem Lannacher is used with caution in AV block of the first degree, intraventricular conduction disorders, in patients prone to arterial hypotension, chronic heart failure, myocardial infarction with left ventricular failure, ventricular tachycardia with expansion of the ORS complex, liver failure, renal failure, in elderly patients, in children (the effectiveness and safety of use is not investigated).

Active ingredient

Diltiazem

Composition

Active ingredient:

diltiazem 0.09 g (90 mg);

Excipients:

lactose monohydrate,

poly(ethyl acrylate, methyl acrylate),

Eudragit NE30D,

methacrylic acid copolymer + Eudragit L100-55,

poly(ethyl acrylate,

methyl methacrylate,

trimethylammonium methyl methacrylate chloride),

Eudragit RS PM,

hydroxypropyl methyl cellulose,

magnesium stearate,

polyethylene glycol,

titanium dioxide,

talc,

antifoaming agent SE2.

Contraindications

pronounced decrease in heart rate
intracardiac conduction disorders
chronic heart failure stage II-III
acute heart failure
hypersensitivity to the drug Diltiazem Lannacher.

Side Effects

From the nervous system and sensory organs: headache, dizziness, fainting, increased fatigue, asthenia, sleep disturbances, drowsiness, anxiety, extrapyramidal (parkinsonism) disorders (ataxia, mask-like face, shuffling gait, stiffness of the arms or legs, trembling of the hands and fingers, difficulty swallowing), depression; when used in high doses – paresthesia, tremor, visual impairment (transient loss of vision).

From the cardiovascular system: asymptomatic decrease in blood pressure; rarely – angina pectoris, arrhythmia (including ventricular flutter and fibrillation), bradycardia (less than 50 beats/min) or tachycardia, AV block II-III degree. up to asystole, development or worsening of heart failure; when used in high doses and with intravenous administration – angina pectoris, bradycardia, AV block, marked decrease in blood pressure, worsening chronic heart failure.

From the digestive system: dry mouth, increased appetite, nausea, vomiting, constipation or diarrhea, increased activity of liver transaminases, gum hyperplasia (bleeding, pain, swelling).

From the hematopoietic system: rarely – thrombocytopenia, agranulocytosis.

Interaction

Potentially dangerous are combinations with beta-blockers, quinidine and other class Ia antiarrhythmic drugs, cardiac glycosides (excessive bradycardia, slowing of AV conduction, decreased myocardial contractility with the development of signs of heart failure).

Procainamide, quinidine and other drugs that cause prolongation of the Q-T interval increase the risk of its significant prolongation. May increase the bioavailability of propranolol. Inhalation anesthesia agents (hydrocarbon derivatives), thiazide diuretics and other drugs that lower blood pressure enhance the hypotensive effect of diltiazem.

Cimetidine increases the concentration of diltiazem in the blood; phenobarbital, diazepam, rifampicin – reduce. Increases blood concentrations of cyclosporine, carbamazepine, theophylline, quinidine, valproic acid and digoxin (dose reduction may be required). Simultaneous administration of nitrates (including prolonged forms) is possible. Strengthens the cardiodepressive effect of general anesthetics.

Li+ preparations may enhance the neurotoxic effects of diltiazem (nausea, vomiting, diarrhea, ataxia, tremors and/or tinnitus). Indomethacin (and other NSAIDs), corticosteroids and estrogens, as well as sympathomimetic drugs reduce the hypotensive effect.

Overdose

Symptoms

bradycardia, atrioventricular conduction disturbances, arterial hypotension.

Treatment:

depending on the severity of the overdose.

It is necessary to rinse the stomach, prescribe activated charcoal, further treatment is symptomatic.

If necessary, it is recommended to prescribe atropine, isoproterenol, dopamine or dobutamine, and also, in case of severe conduction disturbances, the use of cardiac pacing is possible.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

G.L.Pharma GmbH, Austria