Diltiazem, 90 mg 30 pcs

Selective class III calcium channel blocker, benzothiazepine derivative.

Diltiazem has antianginal, hypotensive and antiarrhythmic effect. It reduces myocardial contractility, slows AV conduction, reduces heart rate, reduces myocardial oxygen demand, dilates coronary arteries, increases coronary blood flow. Diltiazem decreases peripheral arterial smooth muscle tone and RPS.

Decreases intracellular calcium ion content in cardiomyocytes and vascular smooth muscle cells, decreases HR, may cause a slight negative inotropic effect, increases coronary, cerebral and renal blood flow.

In concentrations with no negative inotropic effect, Diltiazem causes relaxation of coronary smooth muscle and dilatation of both large and small arteries.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Nervous system and sensory organs: Headache, dizziness, fainting, increased fatigue, asthenia, sleep disturbances, somnolence, anxiety, extrapyramidal (parkinsonism) disorders (ataxia, masked face, shuffling gait, stiffness of hands or feet, trembling hands and fingers, difficulty swallowing), depression; when used in high doses – paresthesias, tremor, visual disturbances (transient vision loss).

Cardiovascular system: asymptomatic decrease of BP; rarely – angina pectoris, arrhythmia (including torsade de pointes and ventricular fibrillation), bradycardia (less than 50 bpm) or tachycardia, AV class II-III blockade. up to asystole, development or worsening of heart failure; when used in high doses and by IV administration – angina pectoris, bradycardia, AV block, marked BP decrease, worsening of chronic heart failure.

Digestive system disorders: dry mouth, increased appetite, nausea, vomiting, constipation or diarrhea, increased liver transaminase activity, gum hyperplasia (bleeding, painfulness, swelling).

With the hematopoietic system: rare – thrombocytopenia, agranulocytosis.

Similarities