Diltiazem, 90 mg 30 pcs
€7.39 €6.47
Selective class III calcium channel blocker, benzothiazepine derivative.
Diltiazem has antianginal, hypotensive and antiarrhythmic effect. It reduces myocardial contractility, slows AV conduction, reduces heart rate, reduces myocardial oxygen demand, dilates coronary arteries, increases coronary blood flow. Diltiazem decreases peripheral arterial smooth muscle tone and RPS.
Decreases intracellular calcium ion content in cardiomyocytes and vascular smooth muscle cells, decreases HR, may cause a slight negative inotropic effect, increases coronary, cerebral and renal blood flow.
In concentrations with no negative inotropic effect, Diltiazem causes relaxation of coronary smooth muscle and dilatation of both large and small arteries.
Indications
Tachycardia, Cardialgia (pain in the heart), Hypertension (high blood pressure), Angina, Arrhythmia Prevention of angina attacks (including Prinzmetal angina).
Arterial hypertension.
Prevention of supraventricular arrhythmias (paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter, extrasystole).
Active ingredient
Diltiazem
Composition
One tablet contains diltiazem chloride 90 mg.
How to take, the dosage
Orally, swallowed whole and washed down with liquids. At 60 mg 3 times a day or 90 mg 2 times a day.
Optimal daily dose of Diltiazem is 180-360 mg.
In in-patients under medical supervision the dose may be increased to 480 mg/day.
Interaction
Potentially dangerous are combinations with beta-adrenoblockers, quinidine and other class Ia antiarrhythmic drugs, cardiac glycosides (excessive bradycardia, delayed AV conduction, reduced myocardial contractility with development of signs of CH). Procainamide, quinidine, etc. Procainamide, quinidine, etc. drugs causing Q-T interval prolongation increase the risk of its significant prolongation.
Special Instructions
Diltiazem is used with caution in Grade I AV-blockade, intraventricular conduction disorders, patients prone to arterial hypotension, chronic heart failure, myocardial infarction with left ventricular failure, ventricular tachycardia with dilation of ORS complex, liver failure, renal failure, elderly patients, children (effectiveness and safety of use are not studied).
Contraindications
Severe bradycardia, grade II and III AV blockade (except for pacemaker patients), CCSU, cardiogenic shock, atrial fibrillation in WPW and Launa-Hanog-Levin syndrome, myocardial infarction with pulmonary congestion, arterial hypotension, chronic heart failure stage II B-III, acute heart failure, hemodynamically significant aortic stenosis, hepatic and renal dysfunction, pregnancy, lactation, hypersensitivity to benzothiazepine derivatives.
Side effects
Nervous system and sensory organs: Headache, dizziness, fainting, increased fatigue, asthenia, sleep disturbances, somnolence, anxiety, extrapyramidal (parkinsonism) disorders (ataxia, masked face, shuffling gait, stiffness of hands or feet, trembling hands and fingers, difficulty swallowing), depression; when used in high doses – paresthesias, tremor, visual disturbances (transient vision loss).
Cardiovascular system: asymptomatic decrease of BP; rarely – angina pectoris, arrhythmia (including torsade de pointes and ventricular fibrillation), bradycardia (less than 50 bpm) or tachycardia, AV class II-III blockade. up to asystole, development or worsening of heart failure; when used in high doses and by IV administration – angina pectoris, bradycardia, AV block, marked BP decrease, worsening of chronic heart failure.
Digestive system disorders: dry mouth, increased appetite, nausea, vomiting, constipation or diarrhea, increased liver transaminase activity, gum hyperplasia (bleeding, painfulness, swelling).
With the hematopoietic system: rare – thrombocytopenia, agranulocytosis.
Similarities
Diltiazem Lannacher, Diltiazem
Weight | 0.016 kg |
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Shelf life | 2 years. |
Conditions of storage | Keep out of the reach of children at temperatures under 25°C. |
Manufacturer | Alkaloid AD Skopje, Republic of Northern Macedonia |
Medication form | sustained release tablets |
Brand | Alkaloid AD Skopje |
Other forms…
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