Diklovit, gel 1% 20 g

The active ingredient diclofenac is a non-steroidal anti-inflammatory drug with pronounced analgesic and anti-inflammatory properties.

Indiscriminately inhibiting cyclooxygenase types 1 and 2, disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins, which are a major link in the development of inflammation.

Diclovit® is used to eliminate pain syndrome and reduce swelling associated with inflammation.

When used externally it relieves or eliminates joint pain at rest and on the move.

It reduces morning stiffness and joint swelling and promotes increase of movement volume in affected joints.

The water-alcohol base of the gel has an additional local anesthetic effect.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

The simultaneous use of the drug Diclovit and: – digoxin, phenytoin, or lithium drugs may increase the plasma levels of these drugs – diuretics and hypotensive drugs –

the effects of these drugs are reduced – potassium-saving diuretics – hyperkalemia may occur – other NSAIDs or glucocorticoids – increased risk of gastrointestinal adverse events

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Acetylsalicylic acid – serum concentration of diclofenac decreases – cyclosporine – increased toxic effects of the latter on the kidneys – antidiabetic agents – hypo or hyperglycemia may be observed.

With this combination of agents it is necessary to control blood sugar levels – methotrexate within 24 hours before or after taking it – may increase methotrexate concentration and its toxic effects – anticoagulants – regular control of blood clotting is necessary.

Special Instructions

Contraindications

Hypersensitivity, including to aspirin or other NSAIDs; gastric or duodenal ulcer in the acute phase; hematopoiesis disorders of unknown etiology; gastrointestinal erosive lesions (acute stage); “aspirin” asthma, “aspirin” triad; pregnancy; children under 6 years old.

With caution: induced acute hepatic porphyria; impaired renal and hepatic function.

Side effects

The side effects that arise depend on individual sensitivity, the amount of dose used, and the duration of treatment.

When using the drug, there may be local irritation of the mucous membrane of the large intestine, mucous discharge with a touch of blood, pain during defecation; gastrointestinal disorders: nausea, vomiting,

anorexia, flatulence, constipation, diarrhea; interstitial nephritis (rarely nephrotic syndrome, papillary necrosis, acute renal failure); headache, dizziness, agitation, insomnia,

irritability, fatigue; skin allergic reactions: exanthema, erythema, eczema, erythema multiforme, Stevens-Johnson syndrome, Lyell syndrome, erythroderma, Quincke’s edema, bronchospasm;

Photosensitization, purpura; hematopoiesis disorders: Anemia – hemolytic and aplastic, leukopenia, agranulocytosis, thrombocytopenia; increased blood pressure; sensory and visual disturbances; seizures.

Similarities