Dihydrotachysterol, drops 1 mg/ml 10 ml

Dihydrotachysterol is a metabolic regulator. Regulator of calcium and phosphorus metabolism. Dihydrotachysterol increases absorption of calcium in the intestine, thereby increasing its level in the blood.

The drug also increases excretion of inorganic phosphorus by the kidneys. Dihydrotachisterol can be used for a long time without the development of overdose effects or tolerance.

The action of the drug is faster at the beginning of treatment and less prolonged after the end of the course than that of vitamin D, due to which the risk of accumulation of the drug in the body and development of hypercalcemia is reduced.

Dihydrotachysterol may exhibit toxic effects at a dose of about 25 mg per day, which is expressed by symptoms of hypercalcemia. It does not cause addictive phenomena.

Indications

Hypoparathyroidism (idiopathic and postoperative), pseudohypoparathyroidism, tetany (muscle cramps caused by hypocalcemia), bone diseases caused by vitamin D deficiency.

Active ingredient

Composition

Active ingredient:

dihydrotachysterol – 1 mg;

Auxiliary substances:

refined deodorized sunflower oil or refined deodorized soybean oil up to 1 ml

How to take, the dosage

In oral administration the daily dose is 0.25-1.5 mg.

The frequency of use depends on the indication and the calcium concentrations in the blood and urine.

Interaction

In concomitant use of dihydrotachysterol with vitamin D, as well as with drugs and food supplements containing calcium, hypercalcemia may occur.

The simultaneous use of dihydrotachysterol with thiazide diuretics and rifampicin may cause hypercalcemia.
Dihydrotachisterol increases the effect of cardiac glycosides and calcium antagonists. When concomitant use of cardiac glycosides or calcium antagonists with dihydrotachisterol the dose of the latter may be reduced.

Barbiturates (phenobarbital), antiepileptic agents [phenytoin (diphenin), carbamazepine (finlepsin), primidone (hexamidine)], anion exchange resins (colestyramine, colestipol) and vaseline oil weaken the pharmacological effects of dihydrotachisterol.

If dihydrotachysterol is simultaneously treated with thyroxine, hypercalcemia may develop after discontinuation.

Contraindications

Hypercalcemia, hypervitaminosis D, hypersensitivity to dihydrotachysterol and other vitamin D preparations.

Side effects

Digestive system: anorexia, nausea, vomiting, diarrhea; when used in high doses – biliary dyskinesia.

Cardiovascular system: palpitation; rarely – disorders of cardiac rhythm.

Metabolic disorders: thirst, calcification of tissues.

Urinary system disorders: with prolonged therapy – renal dysfunction.

Others: pale skin, headache.