Diclofenac-ACOS, gel 5% 30 g

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID).

It has anti-inflammatory, analgesic and antipyretic effects. Inhibits COX enzyme in the cascade of arachidonic acid metabolism and disrupts prostaglandin biosynthesis.

When used externally it has anti-inflammatory and analgesic effects.

Limits and relieves pain at the site of application of the ointment (including joint pain at rest and on movement), reduces morning stiffness and joint swelling. Helps to increase the volume of movement.

Indications

inflammatory and degenerative diseases of the joints (osteochondrosis, osteoarthritis, periarthropathy);
soft tissue rheumatism;
traumatic bruises;
sprains of ligaments, muscles and tendons;
inflammatory swelling of soft tissues;
arthralgia and myalgia caused by heavy physical activity.

Pharmacological effect

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID).

It has anti-inflammatory, analgesic and antipyretic effects. Inhibits the COX enzyme in the arachidonic acid metabolic cascade and disrupts the biosynthesis of prostaglandins.

When applied externally, it has an anti-inflammatory and analgesic effect.

Reduces and relieves pain at the site of application of the ointment (including pain in the joints at rest and during movement), reduces morning stiffness and swelling of the joints. Helps increase range of motion.

Special instructions

Avoid getting Diclofenac gel on damaged skin surfaces, open wounds, eyes and mucous membranes.

Active ingredient

Diclofenac

Composition

Active ingredient:

diclofenac sodium 50 mg.

Contraindications

pathological changes in the blood picture of unknown origin;
peptic ulcer of the stomach and duodenum;
destructive-inflammatory bowel diseases in the acute phase;
pregnancy;
lactation period (breastfeeding should be avoided);
children and adolescents up to 12 years of age (i.m. administration, supp.);
children under 6 years of age (tablets, ointment);
hypersensitivity to acetylsalicylic acid or other NSAIDs (including the “aspirin triad”);
hypersensitivity to diclofenac and other components of the drug;
inflammation of the rectum – proctitis (suppositories)

Side Effects

Skin rash, burning, and redness are possible at the application site.

With prolonged external use of the drug, the development of systemic side effects from the digestive system, central nervous system, respiratory system, as well as allergic reactions is possible.

Interaction

With the simultaneous use of Diclofenac with digoxin, phenytoin or lithium preparations, it is possible to increase the plasma concentrations of these drugs; with diuretics and antihypertensive drugs – the effect of these drugs may be reduced; with potassium-sparing diuretics – hyperkalemia may develop; with acetisalicylic acid – a decrease in the concentration of diclofenac in the blood plasma and an increased risk of side effects.

Diclofenac may enhance the toxic effect of cyclosporine on the kidneys.

Diclofenc can cause hypo- or hyperglycemia, therefore, when used simultaneously with hypoglycemic agents, monitoring of blood glucose concentrations is required.

When using methotrexate within 24 hours before or after taking Diclofenac, the concentration of methotrexate may increase and its toxic effect may increase.

When used simultaneously with anticoagulants, regular monitoring of blood clotting parameters is necessary.

Storage conditions

In a dry place, at a temperature of 15–25 °C

Shelf life

2 years

Manufacturer

Sintez, Russia