Diazolin, 100 mg tablets, 10 pcs.

Pharmacotherapeutic group: anti-allergic agent – H1-histamine receptor blocker.

ATC code: R06AX15

Pharmacological properties

Pharmacodynamics

H1-histamine receptor blocker. It has anti-allergic effect, reduces mucosal edema. It weakens the effect of histamine on the smooth muscles of the bronchi, uterus and intestines, reduces the severity of the reduction of blood pressure and the increase in vascular permeability. Slightly penetrating into the central nervous system, unlike first generation antihistamines, it does not have a pronounced sedative and hypnotic effect. It has weak M-cholinoblocking and anesthetic properties.

Therapeutic effect occurs 15-30 minutes after intake, the maximum effect is observed after 1-2 hours. The duration of the effect may be up to 48 hours.

Pharmacokinetics

It is rapidly absorbed from the gastrointestinal tract (GIT), penetrates all body tissues, but practically does not penetrate through the blood-brain barrier. Bioavailability is 40-60%.

The drug is metabolized in the liver through methylation, induces microsomal liver enzymes and is excreted by the kidneys.

The elimination half-life (T_1/2) from plasma is about 4 hours.

Indications

Active ingredient

Composition

Active substance:

Mebhydroline napadisilate 100 mg;

Associates:

sugar (sucrose);

starch syrup;

talc;

beeswax;

sunflower oil

How to take, the dosage

Overly, without chewing, with or immediately after a meal.

Adults and children over 12 years of age: 100 mg 1-3 times a day. The maximum single dose is 300 mg, the maximum daily dose is 600 mg.

The duration of treatment is determined by the nature of the disease and the therapeutic effect achieved.

In children, the drug is used depending on the age: for children aged from Z to 5 years – 50 mg once or twice a day, from 5 to 10 years – 50 mg 2-3 times a day, from 10 to 12 years – 50 mg 2-4 times a day.

Interaction

Special Instructions

When taking this medication, caution should be exercised when driving vehicles and engaging in other potentially dangerous activities that require high concentration and high-speed psychomotor reactions.

Contraindications

Hypersensitivity to the components of the drug, prostatic hyperplasia, closed-angle glaucoma, gastric and 12 duodenal ulcer, inflammatory gastrointestinal diseases, pilostenosis, epilepsy, cardiac rhythm disorders, pregnancy, lactation, children under 3 years of age.

With caution

Hepatic and/or renal insufficiency (dose and intervals between doses may need to be adjusted.

Side effects

Digestive system disorders: dyspeptic symptoms due to the irritant effect of the drug on the mucous membrane of the gastrointestinal tract (heartburn, nausea, epigastric pain).

Others: dry mouth, urinary retention, allergic reactions, and very rarely – granulocytopenia and agranulocytosis.

Nervous system disorders: dizziness, paresthesias, tremor, increased fatigue, somnolence, anxiety (at night), slowing of psychomotor reactions.

In children, paradoxical reactions are possible: increased excitability, irritability, tremor, sleep disorders.

Overdose

Pregnancy use