Dexa-Gentamicin, eye ointment 2.5g

Pharmacotherapeutic Group: Glucocorticosteroid for topical use + antibiotic aminoglycoside

ATX code: D07CB04.

Pharmacological properties

Pharmacodynamics

A combined agent, the action of which is due to its constituent components, has anti-allergic, anti-inflammatory and antibacterial effects. Dexamethasone is a glucocorticosteroid with a strong anti-inflammatory activity: its relative anti-inflammatory activity index is 30.

Gentamicin sulfate – antibiotic of aminoglycoside group, has a broad spectrum of action: it is active against most gram-negative and gram-positive micro-organisms (Pseudomonas aeruginosa, Escherichia coli, Proteus spp., Klebsiella spp., Serrata spp., Salmonella spp.). Moderately active against strains of Staphylococcus spp.

Pharmacokinetics

When applied topically, dexamethasone penetrates well into the corneal epithelium and conjunctiva; therapeutic concentrations are achieved in the aqueous humor of the eye; when inflammation or damage to the mucosa the rate of penetration increases.

Gentamicin sulfate when applied topically has therapeutic concentrations in the corneal stroma, anterior chamber humor, vitreous humor within 6 hours. Gentamicin sulfate does not penetrate into the systemic bloodstream through the intact corneal epithelium.

Indications

Composition

1 g of eye ointment contains:

The active ingredients:

Dexamethasone 0.3 mg
Gentamicin sulfate 5.0 mg converted to gentamicin 3.0 mg

Excipients:
Vaseline white 775.98 mg

Liquid paraffin 149.13 mg

Lanolin 69.9 mg.

How to take, the dosage

A 1 cm strip of ointment is placed 2 to 3 times daily into the conjunctival cavity.

At the time of application of Dexa-Gentamicin Eye Ointment, avoid contact of the tube with the skin or conjunctiva.

If multiple eye medications are used at the same time, it is recommended that Dexa-Gentamicin Eye Ointment be applied no earlier than 15 minutes after using the eye drops.

The duration of treatment with Dexa-Gentamicin usually does not exceed 2-3 weeks.

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

In rare cases an allergic reaction and burning sensation may occur after application of the ointment.

Long-term use of the drug may cause secondary glaucoma and steroid cataracts, therefore, if the drug is used for more than 2 weeks, and in patients with a history of glaucoma, regular monitoring of intraocular pressure is recommended.

Contact dermatitis, herpetic keratitis, corneal perforation in the presence of keratitis, fungal infection, increased expression of bacterial corneal infection, ptosis, mydriasis are possible. When used after corneal injuries it may lead to delayed corneal healing.

In case of side effects, discontinue use and consult an ophthalmologist as soon as possible.

Overdose

Pregnancy use