Detrimed D3 Vitamin D3 drops 500 IU oil solution, 10 ml

Regulating calcium-phosphorus metabolism.

Pharmacodynamics

Cholecalciferol is a natural form of vitamin D formed in the skin by the action of sunlight. Compared with ergocalciferol 25% more active. Increases absorption of calcium in the intestine and reabsorption of phosphorus in the kidney tubules, normalizes the formation of the bone skeleton, helps maintain bone structure.

Calcium ions in the blood determine the maintenance of muscle tone of the skeletal muscles, myocardial function, promote nerve stimulation, regulate the process of blood clotting. It normalizes the functions of the perischymoid glands, the immune system, and affects the production of lymphokines.

Deficiency of vitamin D in food, impaired absorption, calcium deficiency, as well as lack of exposure to sunlight during rapid growth of the child leads to rickets; in adults – to osteomalacia; pregnant women may show symptoms of tetany, disorders of calcification of bones of newborns. An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal disorders.

Pharmacokinetics

Aqueous solution of vitamin D3 is absorbed better than the oil solution. Premature infants have insufficient bile formation and intestinal intake, which impairs absorption of vitamins in the form of oil solutions.

After oral administration it is absorbed in the distal small intestine. It is metabolized in the liver and kidneys. Passes through the placenta and into the breast milk. It is excreted in the urine and faeces. T1/2 is several days and increases in the case of renal insufficiency. It has the properties of cumulation.

Indications

Composition

How to take, the dosage

For internal use. Prophylaxis: Children: to pre-term newborns from 3-4 weeks of life to 2-3 years old 500-1000 IU (1-2 drops) per day; to premature infants, from 7-10 days of life, to twins, infants in poor living conditions – 1000-1500 IU (2-3 drops) per day.

In summertime, the dose is reduced to 500 IU (1 drop) per day. Pregnant women 500 IU (1 drop) per day for the duration of pregnancy or 1000 IU (2 drops) per day starting at 28 weeks of pregnancy. In the postmenopausal period – 500-1000 IU (1-2 drops) per day.

The treatment: with rickets, daily 2000 – 5000 IU (4-10 drops) depending on the severity of rickets (I, II, III), and the course variant, for 4-6 weeks, or the initial dose of 2000 IU (4 drops) for 3-5 days, with good tolerance – up to 3000 IU (6 drops), with pronounced bone changes – up to 5000 IU (10 drops). If necessary, the course of treatment is repeated in 1 week.

After the therapeutic effect is achieved, the prophylactic administration is switched to (500-1500 IU/day). Cancer-like diseases – 20000-30000 IU/day (40-60 drops), the treatment course of 4-6 weeks. In postmenopausal osteoporosis (complex treatment) – 500-1000 IU/day (1-2 drops).

Interaction

Special Instructions

Overdose should be avoided. Too high doses of vitamin D3, used for a long time, or shock doses can cause chronic hypervitaminosis D3. When determining the dose of vitamin D, the amount of vitamin D taken with food must be taken into account.

The determination of the child’s daily vitamin D requirement and the way it is taken is individualized by the doctor and monitored periodically, especially in the first months of life.

With caution should be used in patients with prolonged immobilization.

The simultaneous administration of high doses of calcium should be avoided.

The calcium levels in blood and urine should be monitored during treatment.

Contraindications

Overdose

Symptoms: decreased appetite, nausea, vomiting, constipation, restlessness, thirst, polyuria, diarrhea, renal colic. Headache and muscle and joint pain, mental disorders (depression), stupor, ataxia, progressive weight loss. Renal function disorder with albuminuria, erythrocyturia, polyuria, hyperkaluria, hypostenuria, nycturia, increased blood pressure. In severe cases – corneal clouding, edema of optic nerve papilla, iris inflammation (up to cataract development). Calcium nephrourolithiasis, systemic calcinosis may develop. Rarely, cholestatic jaundice.

Treatment: withdrawal of the drug. Symptomatic, supportive therapy. Taking plenty of fluids.