Detrimed D3 Vitamin D3 drops 500 IU aqueous solution, 10 ml

Regulating calcium-phosphorus metabolism.

Pharmacodynamics

Cholecalciferol is a natural form of vitamin D formed in the skin by sunlight. Compared with ergocalciferol 25% more active. Increases absorption of calcium in the intestine and reabsorption of phosphorus in the kidney tubules, normalizes the formation of the bone skeleton, helps maintain bone structure.

Calcium ions contained in the blood determine the maintenance of muscle tone of the skeletal muscles, myocardial function, promote nerve stimulation, regulate the process of blood clotting. It normalizes the functions of the perischymoid glands, the immune system, and affects the production of lymphokines.

Deficiency of vitamin D in food, impaired absorption, calcium deficiency, as well as lack of exposure to sunlight leads to osteomalacia in adults; symptoms of tetany may occur in pregnant women. An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal disorders.

Pharmacokinetics

After oral administration, it is absorbed in the distal small intestine. It is metabolized in the liver and kidneys. Passes through the placenta and into the breast milk. It is excreted in the urine and faeces. T1/2 is several days and increases in the case of renal insufficiency. It has the properties of cumulation.

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Indications

Composition

One milliliter of solution (30 drops) contains 15,000 IU of cholecalciferol

(1 drop contains 500 IU of vitamin D3)

Excipients: Macrogoal glycerylicinoleate, sucrose 250 mg, diatrium phosphate dodecahydrate, citric acid monohydrate, banana flavoring, benzyl alcohol 15mg, purified water.

How to take, the dosage

Interaction

Special Instructions

Overdose should be avoided. Overdoses of vitamin D3 administered for long periods or shock doses can cause chronic hypervitaminosis D3. When determining the dose of vitamin D, the amount of vitamin D taken with food must be taken into account.

With caution should be used in patients with prolonged immobilization.

The simultaneous ingestion of high doses of calcium should be avoided.

Blood and urine calcium levels should be monitored during treatment.

Contraindications

Individual hypersensitivity to cholecalciferol, including a history.

Individual intolerance to benzyl alcohol.

Elevated blood calcium levels (hypercalcemia).

Elevated calcium levels in the urine (hypercalciuria).

Hypervitaminosis D.

Legal stone disease with deposition of calcium oxalate.

Inadequate renal function.

Active form of pulmonary tuberculosis.

Large doses of the drug are contraindicated in prolonged immobilization.

The drug is prescribed with caution during pregnancy and lactation.

In patients with atherosclerosis, sarcoidosis, hyperphosphatemia, acute and chronic kidney and liver diseases. In disorders of the gastrointestinal tract, particularly with gastric ulcer and duodenal ulcer. With organic lesions of the heart, such as pericarditis, myocarditis, etc.

Overdose

Symptoms: decreased appetite, nausea, vomiting, constipation, restlessness, thirst, polyuria, diarrhea, renal colic. Headache and muscle and joint pain, mental disorders (depression), stupor, ataxia, progressive weight loss. Renal function disorder with albuminuria, erythrocyturia, polyuria, hyperkaluria, hypostenuria, nycturia, increased blood pressure. In severe cases – corneal clouding, edema of optic nerve papilla, iris inflammation (up to cataract development). Calcium nephrourolithiasis, systemic calcinosis may develop. Rarely, cholestatic jaundice.

Treatment: withdrawal of the drug. Symptomatic, supportive therapy. Taking plenty of fluids.

Pregnancy use