Dasolik, 500 mg 10 pcs

An antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. Mechanism of action consists in biochemical reduction of 5-nitrogroup of ornidazole by intracellular transport proteins of anaerobic bacteria and protozoa. The reduced 5-nitrogroup of ornidazole interacts with the DNA of the cells of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of the bacteria.

It is active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica as well as anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. Aerobic microorganisms are not sensitive to ornidazole.

Absorption from the gastrointestinal tract is high. Bioavailability – 90%. Time to reach maximum concentration (TCmax) – 1-2 hours. Binding to plasma proteins – less than 15%. Metabolized in the liver by hydroxylation, oxidation and glucuronidation. T1/2 is 12-14 hours. It penetrates into breast milk and most tissues, passes through the blood-brain barrier and the placenta.

The elimination half-life (T1/2) is about 13 hours. It is excreted as metabolites by kidneys (60-70%) and with feces (20-25%), about 5% of dose is excreted unchanged.

Indications

Trichomoniasis, amebiasis, amebic dysentery, extraintestinal amebiasis (including amebic liver abscess); giardiasis; prevention of infections caused by anaerobic bacteria, during operations on the colon and in gynecology.

Active ingredient

Composition

Each tablet contains:

Active ingredients:

Ornidazole – 500.0 mg

Associates:

Starch,

Microcrystalline cellulose,

Sodium lauryl sulfate,

povidone-C90,

purified talc,

magnesium stearate,

colloidal silicon dioxide,

sodium carboxymethyl starch (type A),

butyl methacrylate,

dimethylaminoethyl methacrylate and methyl methacrylate copolymer [1:2:1] (Eudragit E 100),

Titanium dioxide,

Macrogol-6000.

How to take, the dosage

The tablets are taken orally, after meals.

In trichomoniasis: adults, 1.5 g once or 1 g in combination with intravaginal administration of 500 mg (vaginal tablets) at night. It is possible to spend treatment during 5 days, prescribing 500 mg orally 2 times a day (morning and evening), also with the appointment of 1 vaginal tablet 500 mg at night. In children – in a single dose, at a rate of 25 mg/kg.

In case of amebic dysentery in adults and children with body weight over 35 kg – 1.5 g once daily, if body weight over 60 kg – 2 g/day. For children older than 3 years and with body weight less than 35 kg – 40 mg/kg/day. The course of treatment is 3 days.

For treatment of other forms of amoebiasis: adults and children over 12 years of age – 0.5 g 2 times a day for 5-10 days. For children over 3 years of age and with body weight less than 35 kg – 25 mg/kg once for 5-10 days.

In case of giardiasis: to adults and children with body mass over 35 kg – 1.5 g 1 time per day; to children older than 3 years old and with body mass less than 35 kg – 40 mg/kg/day. The duration of treatment is 1 to 2 days.

Prophylaxis of infections caused by anaerobic bacteria – 0.5-1 g before surgery, after surgery – 0.5 g 2 times a day for 3-5 days.

Interaction

It enhances the effect of indirect coumarin anticoagulants, prolongs the myorelaxant effect of vecuronium bromide.

Compatible with ethanol (does not inhibit acetaldehyde dehydrogenase) unlike other imidazole derivatives (metronidazole).

Special Instructions

In the treatment of trichomoniasis, both sexual partners should be treated concomitantly.

Impact on the ability to drive vehicles and operate machinery.

Contraindications

Hypersensitivity. Children under 3 years of age (for this dosage form).

With caution

Side effects

Sleepiness, headache, gastrointestinal dysfunction (including nausea), dizziness, tremor, muscle rigidity, movement coordination disorders, seizures, fatigue, temporary loss of consciousness, sensory or mixed peripheral neuropathy, perversion of taste sensation, increased activity of “liver” enzymes, allergic reactions.

Overdose

Symptoms: seizures, depression, peripheral neuritis.

Treatment: symptomatic (diazepam in convulsions).

Pregnancy use

The drug is contraindicated in the first trimester of pregnancy and during lactation (breast-feeding).

Similarities