Cyprinol, 500 mg 10 pcs

Cyprinol refers to antibacterials for systemic use. Fluoroquinolones.

Ciprofloxacin inhibits the enzyme DNA-gyrase, inhibiting the ability of bacteria to reproduce. The drug has a bactericidal effect on microorganisms both during the reproduction phase and in the quiescent phase.

Cyprinol is highly effective against almost all Gram-negative and Gram-positive pathogens. To ciprofloxacin are sensitive: Salmonella spp., Shigella spp, Klebsiella spp., Escherichia coli, Citrobacter spp., Enterobacter spp., Hafnia spp, Serratia spp., Edwardsiella spp., Proteus, Providencia spp., Morganella spp., Aeromonasspp., Yersinia, Vibriospp., Haemophilus, Plesiomonas, Campylobacterspp., Pasteurella, Pseudomonasspp. (Including Pseudomonas aeruginosa), Neisseria spp., Legionella, Moraxella spp., Acinetobacter spp., Branhamella spp., Brucella spp., Listeria spp., Staphylococcus spp., Corynebacterium, Chlamydia, and plasmid forms of bacteria.

Different sensitivities show: Gardnerella spp., Streptococcus agalactiae, Alcaligenes spp., Flavobacterium spp., Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae, Mycoplasma hominis, Streptococcus viridans, Mycobacterium fortuitum, Mycobacterium tuberculosis. Anaerobic cocci (Pertococcus, Peptostreptococcus) are moderately sensitive to ciprofloxacin, and Bacteroides is resistant.

Ciprofloxacin is effective against beta-lactamase-producing bacteria. Ciprinol is active against microorganisms resistant to most antibiotics, sulfonamides and nitrofurans. Ciprofloxacin may be active against strains of microorganisms resistant to other drugs of fluoroquinolone group.

But it should be taken into account that there is cross-resistance between different fluoroquinolones. As a rule, Nocardia asteroides, Treponema pallidum, Streptococcus faecium, Ureaplasma urealyticum are resistant to Ciprinol. Resistance to ciprofloxacin develops slowly and gradually.

Indications

Active ingredient

Composition

1 tablet contains:

Nucleus:

Active ingredient:

Ciprofloxacin as ciprofloxacin hydrochloride monohydrate 291 mg (corresponding to ciprofloxacin 250 mg).

Auxiliary substances:

Microcrystalline cellulose,

sodium carboxymethyl starch (type A),

povidone,

croscarmellose sodium,

colloidal anhydrous silicon dioxide,

magnesium stearate.

Wrapping:

Hypromellose, talc, titanium dioxide, E171, propylene glycol.

How to take, the dosage

In urinary tract infections take Cyprinol at 0.125 – 0.5 g 2 times a day, in more severe cases – up to 0.75 g 2 times a day. The course of treatment is usually 5 to 15 days.

In gonorrhea 0.5 g once. In particularly severe infectious diseases and when it is impossible to take tablets orally, it is started with intravenous administration of Ciprinol.

Interaction

When ciprofloxacin is combined with antacids (which contain aluminum, magnesium or calcium) or sucralfate, absorption of ciprofloxacin is reduced. Therefore, it is recommended that ciprofloxacin be taken either 4 hours before antacids or sucralfate, or 2-4 hours after they are taken.

Drugs containing iron or zinc reduce absorption of ciprofloxacin. Concomitant use of ciprofloxacin and theophylline and/or caffeine may cause increased serum levels of theophylline and/or caffeine and increase their elimination time. The risk of these side effects increases. Concomitant administration of ciclosporin and ciprofloxacin increases nephrotoxicity of ciclosporin. Control of serum concentrations of theophylline and cyclosporine is necessary. Combination of ciprofloxacin and oral anticoagulants may increase bleeding time, therefore prothrombin time should be controlled.

When treating with ciprofloxacin, there is a high risk of tendon rupture in patients who are concomitantly treated with corticosteroids. Combined administration of ciprofloxacin and phenytoin may lead to changes in the serum concentration of phenytoin. Caution should be exercised when prescribing Ciprinol in patients with diabetes mellitus, because the effect of glibenclamide may increase and cause hypoglycemia. Concomitant use with NSAIDs (especially opioid analgesics) and very high doses of quinolones may cause seizures.

Special Instructions

Should not be administered simultaneously with antacids, the interval between the use of these drugs should be at least 2 hours. During treatment, it is necessary to get enough fluids and sunbathing is not recommended.

In case of joint and ligament pain, treatment with Cyprinol should be discontinued. Do not take concomitantly with antiarrhythmic drugs of classes I and III, tricyclic antidepressants.

Contraindications

Side effects

Overdose

Symptoms: nausea, vomiting, diarrhea, headache and dizziness, and in more severe cases confusion, tremors, hallucinations and seizures.

Treatment: symptomatic, gastric lavage, administration of activated charcoal and laxatives; ensure adequate fluid intake. A specific antidote is unknown. Hemodialysis has no clinical effect in intoxication.

Similarities