Colophort, tablets 100 pcs

It was shown experimentally that the components of the preparation modify the activity of ligand-receptor interaction of endogenous regulators with the corresponding receptors: antibodies to protein S-100 – to serotonin receptors and sigma 1 receptors; antibodies to TNF- a – to TNF receptor a; antibodies to histamine – to H4 – histamine receptors localized in the gastrointestinal tract (GIT).

The combination of three active components allows a complex influence on central and peripheral links of pathogenesis of functional intestinal disorders, including abdominal pain syndrome. Antibodies to protein S-100 have a wide range of psychotropic activity, including anxiolytic and antidepressant, anti-asthenic and nootropic effects, which is clinically manifested in the elimination of internal tension, anxiety, normalization of several visceral functions, including the activity of the large intestine.

Antibodies to TNF-a has a marked anti-inflammatory effect, helps normalize the balance of pro-inflammatory and anti-inflammatory cytokines.

Antibodies to histamine have antispasmodic, anti-inflammatory, anti-edema effects. Combined use of the components in a complex drug contributes to the normalization of the nervous and humoral regulation of intestinal function, a decrease in visceral hypersensitivity of the colon receptors to distension, thus restoring impaired motility of the gastrointestinal tract; relief of bloating and overfilling of the stomach, a decrease in the severity of pain. Antispasmodic action of the drug is manifested by relaxation of smooth muscles and reduction of GIT wall tone, decrease of intraluminal pressure, normalization of stool consistency, frequency and related symptoms (relief of imperative urges, tenesmus, incomplete bowel emptying, additional efforts during defecation, etc.).

Pharmacokinetics

The sensitivity of modern physico-chemical methods of analysis (gas-liquid chromatography, high-performance liquid
Chromatography, chromatography-mass spectrometry) does not allow assessing the content of active substances of the drug Colofort in biological
fluids, organs and tissues, which makes it technically impossible to study pharmacokinetics.

Indications

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