Coldact with vitamin C, 10 pcs.

Pharmacological properties

Combined drug, has antipyretic, anti-inflammatory, anti-edema, analgesic and anti-allergic effect, eliminates the symptoms of “colds”.

Pharmacodynamics

Paracetamol. It has analgesic and antipyretic effect similar to that of salicylates. Paracetamol also has weak anti-inflammatory activity. In equal doses, the degree of analgesic and antipyretic effect is comparable to that of aspirin.

Paracetamol reduces body temperature in patients with fever, but rarely reduces the normal temperature. The antipyretic effect is through the hypothalamus. Fever reduction is achieved due to vasodilation and increased peripheral blood flow.

Phenylephrine hydrochloride. It is a vasoconstrictor of sympathomimetics group. It has direct effect on a-adrenergic receptors. In therapeutic doses it does not affect β1-adrenergic receptors of the heart. Phenylephrine does not stimulate β2-adrenergic receptors of the bronchi or peripheral blood vessels.

α-adrenergic effects are thought to result in suppression of cyclic adenosine-3,5-monophosphate (cAMP) production by inhibiting adenyl cyclase, whereas β-adrenergic effects are caused by increased adenyl cyclase activity.

Phenylephrine indirectly promotes noradrenaline release. Vasoconstriction is the main effect of phenylephrine in therapeutic doses.

Chlorphenamine maleate. It has a pronounced antagonistic effect on H1-receptors of histamine. Antihistamines reduce or eliminate the effects of histamine through reversible binding of H1-receptor histamine in tissues.

Chlorphenamine also has anticholinergic activity. Antihistamines inhibit the release of histamine, prostaglandins, leukotrienes, and migration of inflammatory mediators.

The action of chlorpheiamine includes inhibition of histamine in smooth muscle tissue, reduction of capillary permeability and thereby reducing edema in allergic reactions.

Ascorbic acid (vitamin C). It replenishes the increased need for vitamin C during colds and flu, especially in the initial stages of the disease. Increases the body’s resistance to infections, improves the tolerance of paracetamol. Participates in various biochemical oxidation-reduction reactions.

It is an effective antioxidant. Taking ascorbic acid soothes the course of the disease and shortens its duration.

Pharmacokinetics:

Paracetamol. It is rapidly and almost completely absorbed from the gastrointestinal tract. Maximum plasma concentrations are reached 10-60 minutes after oral administration.

Paracetamol is widely distributed in all body tissues. It penetrates the placental barrier and is secreted with breast milk. Binding to plasma proteins is low at normal therapeutic concentrations, but increases with increasing concentrations.

Paracetamol is metabolized in the liver primarily by two pathways: glucuronidation and sulfation. Excreted by the kidneys, mainly as conjugates of glucuronide and sulfate. The elimination half-life is from 1 to 3 hours.

In severe renal impairment (creatinine clearance less than 30 ml/min) excretion of paracetamol and its metabolites is delayed.

Phenylephrine hydrochloride. Absorbed from the gastrointestinal tract and metabolized by monoamine oxidase during primary passage through the intestinal wall and in the liver, so when ingested phenylephrine hydrochloride has limited bioavailability. It is excreted by the kidneys almost completely in the form of sulfate conjugate.

Maximal concentration of the drug in plasma is reached within 45 minutes to 2 hours and half-life period of the drug from plasma is 2-3 hours.

Chlorphenamine maleate. It is relatively slowly absorbed from the gastrointestinal tract, maximum concentrations of chlorphenamine in plasma are achieved 2.5-6 hours after taking the drug.

The substance has low bioavailability of 25-50%. About 70% of chlorphenamine in bloodstream is bound to plasma proteins. It is widely distributed in body tissues including central nervous system (CNS).

Chlorphenamine undergoes significant metabolism during primary passage. The duration of action is 4-6 hours. In children, faster and more complete absorption, faster clearance, and a shorter half-life were noted.

The half-life is 2 to 43 hours, even with an average duration of action of 4-6 hours. Part of chlorphenamine unchanged with metabolites was excreted by the kidneys.

Ascorbic acid. It is easily absorbed after oral administration. Under normal dosing regimen (30-180 mg/day) about 70-90% of the vitamin is absorbed; further increasing the dose reduces absorption (50-20%).

Ascorbic acid is widely distributed in tissues. High concentrations of the vitamin are found in the liver, white blood cells, platelets, glandular tissue and the lens of the eye. About 25% of the vitamin is bound to plasma proteins. Ascorbic acid passes through the placental barrier. The concentration in umbilical cord blood is usually 2-4 times higher than in maternal blood.

Ascorbic acid is reversibly oxidized to dehydroascorbic acid. Some amount is metabolized to inactive derivatives (sulfates and oxalates) and excreted in the urine.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Hypersensitivity to the components of the drug.

The use of monoamine oxidase inhibitors (simultaneously or in the previous 14 days), tricyclic antidepressants, beta-adrenoblockers, other sympathomimetics.

Severe cardiovascular disease, arterial hypertension, hyperthyroidism, closed-angle glaucoma, pheochromocytoma.

Pregnancy, period of breastfeeding.

Children under 12 years of age.

Diabetes mellitus, impaired liver function, impaired renal function, prostatic hyperplasia, hemolytic anemia, bronchial asthma, chronic obstructive pulmonary disease (chronic bronchitis), pulmonary emphysema, acute hepatitis, chronic exhaustion or dehydration, pyloroduodenal stenosis, epilepsy, cardiovascular disease, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia.

Do not take other paracetamol-containing drugs simultaneously, as well as other drugs that affect liver function.

Patients with alcohol dependence and recurrent kidney stone formation should be taken with caution.

Side effects

Overdose

Pregnancy use