Co-trimoxazole, 240 mg/5 ml suspension 100 g

Pharmacotherapeutic group: antimicrobial combination medicine

ATX code: J01EE01

Pharmacodynamics:

Indications

– Infections of the genitourinary organs: urethritis cystitis pyelonephritis prostatitis epididymitis gonorrhea soft chancre venereal lymphogranuloma inguinal granuloma;

– Respiratory infections: bronchitis (acute and chronic) bronchiectatic disease lumpy pneumonia bronchopneumonia pneumocystis pneumonia;

– ENT organ infections: otitis media sinusitis laryngitis angina; scarlatina; infections of the gastrointestinal tract: typhoid fever paratyphoid salmonellosis cholera dysentery cholecystitis cholangitis gastroenteritis caused by enterotoxic strains of Escherichia coli;

– skin and soft tissue infections: acne furunculosis pyoderma wound infections;

– osteomyelitis (acute and chronic), etc. osteoarticular infections brucellosis (acute) South American blastomycosis malaria (Plasmodium falciparum) toxoplasmosis (in complex therapy).

Active ingredient

Composition

100 ml of the suspension contain:

The active ingredients:

Sulfamethoxazole 4000 mg,

Trimethoprim 800 mg.

How to take, the dosage

The dosing regimen is individual, depending on the severity of the disease sensitivity and type of pathogen the age of the patient. In case of uncomplicated infections it is prescribed:

From 3 months to 6 months, 25 ml of suspension 2 times a day;

From 6 months to 6 years, 25 – 5 ml of suspension 2 times a day;

From 6 to 12 years of age – 5 – 10 ml of suspension, 2 times a day;

After 12 years of age and adults – 10-20 ml of suspension, 2 times a day.

The course of treatment lasts from 5 to 14 days.

The drug is taken with or after meals. It is recommended to drink plenty of fluids during the treatment.

If the course of treatment is prolonged for more than 5 days and/or the dose is increased, haematological control is necessary; in case of changes in blood picture, administration of folic acid 5-10 mg per day is necessary.

Interaction

Special Instructions

In case of prolongation of the treatment course for more than 5 days and/or increasing the dose it is necessary to conduct hematological control; in case of changes in the blood picture it is necessary to administer folic acid 5-10 mg per day.

Contraindications

Hypersensitivity (including to sulfonamides) hepatic and/or renal insufficiency (creatinine clearance less than 15 ml/min) aplastic anemia B 12-deficiency anemia agranulocytosis leukopenia glucose-6-phosphate dehydrogenase deficiency pregnancy lactation period childhood age (up to 3 months) hyperbilirubinemia in children.

Folic acid deficiency bronchial asthma thyroid disease.

Side effects

Nervous system: headache dizziness; in some cases – aseptic meningitis depression apathy tremor peripheral neuritis.

Respiratory system: bronchospasm pulmonary infiltrates.

In the digestive system: nausea vomiting decreased appetite diarrhea gastritis abdominal pain glossitis stomatitis cholestasis increased activity of “hepatic” transaminases hepatitis hepatonecrosis pseudomembranous enterocolitis.

Hematopoietic organs: leukopenia neutropenia thrombocytopenia agranulocytosis megaloblastic anemia.

Arenal system disorders: polyuria interstitial nephritis renal dysfunction crystalluria hematuria increased concentration of urea hypercreatininemia toxic nephropathy with oliguria and anuria.

Musculoskeletal system disorders: arthralgia myalgia.

Allergic reactions: itching photosensitization rash erythema multiforme (including Stevens-Johnson syndrome) toxic epidermal necrolysis (Lyell syndrome) exfoliative dermatitis allergic myocarditis body temperature increase angioedema scleric hyperemia.

Overdose

Symptoms: nausea vomiting intestinal colic dizziness headache sleepiness depression fainting confusion visual disturbance fever hematuria crystalluria; in prolonged overdose – thrombocytopenia leukopenia megaloblastic anemia jaundice.

Treatment: gastric lavage, acidification of the urine increases trimethoprim excretion, oral fluid intake – 5-15 mg/day calcium folinate (eliminates the effect of trimethoprim on the bone marrow), if necessary – hemodialysis.

Similarities