Clotrimazol-Teva, cream 1% 30 g
€9.43 €8.25
Pharmacotherapeutic group: antifungal agent.
The ATX code: [D01AC01].
Pharmacological properties
Pharmacodynamics
Clotrimazole-Teva is a broad spectrum antifungal agent for external use. Antimycotic effect of the active active substance clotrimazole (imidazole derivative) is associated with disruption of ergosterol synthesis, which is part of the cell membrane of fungi, which changes the membrane permeability and causes subsequent cell lysis. At low concentrations it is fungistatic and at high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also contributes to the destruction of fungal cells.
It is effective against dermatophytes, yeast-like and mold fungi as well as against the causative agent of variegated lichen Pityriasis versicolor (Malazessia furfur and the causative agent of erythrazma. It has antimicrobial action against Gram-positive (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.
In vitro at a concentration of 0.5-10 µg/ml, clotrimazole inhibits the reproduction of bacteria of the family Corynebacteria and Gram-positive cocci (except enterococci) and has a trichomonacid effect at a concentration of 100 µg/ml.
Pharmacokinetics
Clotrimazole is poorly absorbed through the skin and mucous membranes and has almost no systemic action. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes. When applied externally, the concentration of clotrimazole in the epidermis is higher than in the dermis and subcutaneous tissue.
Indications
Active ingredient
Composition
How to take, the dosage
Externally. The cream is applied in a thin layer 2-3 times a day to previously cleansed (using soap with a neutral pH) and dry affected skin and rubbed gently.
The duration of treatment depends on the severity of the disease, localization of pathological changes and the effectiveness of therapy.
The treatment of dermatomycoses lasts at least 4 weeks, pityriasis – 1-3 weeks.
In case of fungal skin diseases of the feet the therapy is recommended to be continued for at least 2 more weeks after cessation of symptoms.
Interaction
Special Instructions
Application to the skin in the eye area is not recommended.
When treating onychomycosis, care should be taken to ensure that the nail plates to be treated are trimmed short or have a roughened surface for better penetration of the active ingredient. In these cases, preference should be given to the solution because of the best, penetrating properties. In patients with hepatic insufficiency the functional status of the liver should be periodically monitored.
In case of signs of hypersensitivity or irritation, treatment should be discontinued.
If there is no effect within 4 weeks, the diagnosis should be confirmed.
Synopsis
Contraindications
Side effects
Overdose
Pregnancy use
Similarities
Weight | 0.050 kg |
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Shelf life | 2 years. After opening the tube the drug is suitable for use within 1 year. Do not use after the expiration date! |
Conditions of storage | Store at a temperature not exceeding 25 ° C. Keep out of reach of children! |
Manufacturer | Merkle GmbH, Germany |
Medication form | exterior cream |
Brand | Merkle GmbH |
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