Clobir, 400 mg capsules 100 pcs

Clodronic acid belongs to the group of bisphosphonates and is an analogue of natural pyrophosphate. The action of bisphosphonates is based on a high affinity for the mineral components of bone tissue. The main mechanism of action of clodronic acid is inhibition of osteoclast activity and reduction of bone tissue resorption mediated by them.

Indications

osteolytic metastases of malignant tumors in the bone and myeloma disease (multiple myeloma);
– prevention of bone metastases of primary breast cancer;
– hypercalcemia due to malignant tumors.

Active ingredient

Clodronic acid

How to take, the dosage

Oral. 400 mg capsules should be swallowed without chewing. The daily dose of 1600 mg should be taken once in the morning on an empty stomach with a glass of water. After taking Klobir, the patient should refrain from eating, drinking (except plain water) and taking other medicines within one hour.

Interaction

There is evidence of an association between taking clodronic acid and impaired renal function with concomitant prescription of nonsteroidal anti-inflammatory drugs, most commonly diclofenac.

Special Instructions

Before and during treatment, ensure adequate intake of fluids to the patient, and monitor renal function and serum calcium concentration.

Contraindications

– Pregnancy and lactation;
– concomitant therapy with other bisphosphonates;
– childhood (due to lack of clinical experience);