Clindamycin-Vertex, 2% vaginal cream 20 g

Bacteriostatic antibiotic from the group of lincosamides, has a broad spectrum of action, binds to 50S subunit of ribosomal membrane and inhibits protein synthesis in the microbial cell.

Bactericidal action is possible against a number of Gram-positive cocci.

Active against Staphylococcus spp. (including Staphylococcus epidermidis producing and non-producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp, anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacterium spp., and Actinomyces israelii.

Most strains of Clostridium perfringens are sensitive to clindamycin, but other species of Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action; therefore, in infections caused by Clostridium spp.
There is cross-resistance between clindamycin and lincomycin.

Indications

Vaginitis caused by drug-sensitive microorganisms.

Active ingredient

How to take, the dosage

Intravaginal: vaginal cream is administered in a single dose of 100 mg of clindamycin (1 applicator) at night, the course of treatment is 3-7 days.

Interaction

Incompatible with solutions containing vitamin B complex, aminoglycosides, ampicillin, phenytoin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.

In vitro antagonism of clindamycin with erythromycin as well as with chloramphenicol has been shown; since this effect may be clinically significant, these drugs should not be taken simultaneously.

Because clindamycin interferes with neuromuscular transmission and may potentiate the effects of peripheral myorelaxants, caution should be exercised and the patient should be closely monitored during concomitant use.

Concomitant use with opioid (narcotic) analgesics may increase respiratory depression up to apnea. Concomitant use with antidiarrheal drugs that reduce gastrointestinal motility increases the risk of pseudomembranous colitis.

Special Instructions

Vaginal cream is not recommended for use simultaneously with other intravaginal medications.

Contraindications

Hypersensitivity, pregnancy I trimester (for vaginal cream).

Side effects

Allergic reactions (including skin rash, urticaria).

Irritation at the application site, cervicitis, vaginitis, the development of superinfection (fungal vaginitis).

Overdose

Symptoms: increased severity of side effects.

Treatment:symptomatic and supportive. Not excreted by hemodialysis and peritoneal dialysis.

Pregnancy use

In pregnancy it is possible if the expected effect of therapy exceeds the potential risk to the fetus (adequate and strictly controlled studies in pregnant women have not been conducted, clindamycin passes through the placenta and may concentrate in the fetal liver, but no complications in humans have been reported).

The studies have not determined whether treatment of bacterial vaginosis reduces the risk of adverse pregnancy outcomes such as premature rupture of membranes, premature onset of labor, or premature delivery.

Caution should be exercised when using during breastfeeding (it is not known whether clindamycin penetrates into breast milk after external and intravaginal administration, but is detectable in breast milk after oral or parenteral administration).

Similarities