Clindamycin, 150 mg capsules 16 pcs
€6.00 €5.12
Clindamycin is a drug from the group of antibiotics – lincosamides, has a broad spectrum of action, bacteriostatic, binds to the 50S ribosome subunit and inhibits protein synthesis in microorganisms.
Active against:
– Staphylococcus spp. (including penicillinase-producing Staphylococcus epidermidis).
– Streptococcus spp. (excluding Enterococcus spp.).
– Streptococcus pneumoniae.
– Anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.).
– Corynebacterium diphtheriae.
– Clostridium perfringens.
– Clostridium tetani.
– Mycoplasma spp.
– Bacteroidesspp. (including Bacteroides fragilis and Bacteroides melaningenicus).
– Anaerobic Gram-positive, non-spore-forming bacilli (including Propionibacterium spp., Eubacterium spp., Actinomyces spp.).
Most strains of Clostridium perfringens are sensitive to clindamycin, but other species of clostridia (Clostridium sporogenes, Clostridium tertium) are resistant to the drug, so in infections caused by Clostridium spp.
In terms of mechanism of action and antimicrobial spectrum the drug is close to lincomycin (it is 2-10 times more active against some types of microorganisms, especially against bacteroides and non-sporulating anaerobes).
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to clindamycin:
– Upper respiratory tract infections and ENT organ infections
– Pharyngitis.
– Tonsillitis.
– Sinusitis.
– Otitis media.
– Pneumonia, including aspiration.
– Lung abscess.
– Pleural empyema.
– Bronchitis.
– Chlamydia.
– Endometritis.
– Vaginal infections.
– Tuberovarian inflammation.
– Infected wounds.
– Abscesses.
– Boils.
– Panarritis.
– Abdominal cavity:
– Peritonitis.
– Abscess.
Active ingredient
Composition
In 1 capsule contains:
Clindamycin (in hydrochloride form) 150 mg.
Auxiliary substances:
Corn starch,
Lactose monohydrate,
Talc,
Magnesium stearate.
Capsule body composition:
Dye azorubin (E122),
Dye diamond black (E151),
Gelatin.
Capsule cap composition:
Titanium dioxide (E171),
Quinoline yellow dye (E104),
Azorubin dye (E122),
How to take, the dosage
– Orally, adults and children over 15 years of age (average child weight 50 kg or more) in diseases of moderate severity are prescribed 1 capsule (150 mg) 4 times a day (every 6 hours).
– In severe infections in adults and children over 15 years old a single dose may be increased to 2-3 capsules (300-450 mg).
– For children from 8 to 15 years of age, the method of capsule administration is shown in the table.
In case of intravenous and intravenous administration, the recommended dose is:
– For adults, 300 mg 2 times a day. For severe infections, up to 1.2-2.7 g/day divided into 3-4 injections.
– For children over 3 years of age – 15-25 mg/kg/day, divided into 3-4 equal doses. In severe infections, the daily dose may be increased to 25-40 mg/kg body weight divided into 3-4 equal injections.
Patients with severe hepatic and/or renal impairment do not require a dosing regimen adjustment if the drug is administered at least 8 hours apart.
Interaction
Clindamycin enhances (mutually) the effect of rifampicin, aminoglycosides, streptomycin, gentamicin (especially in the treatment of osteomyelitis and prevention of peritonitis after intestinal perforation).
It enhances the effect of competitive myorelaxants and also enhances myorelaxation caused by n-cholinoblockers.
Incompatible with ampicillin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.
It shows antagonism with erythromycin and chloramphenicol .
The concomitant use with solutions containing B-complex vitamins, aminoglycosides, phenytoin is not recommended.
Simultaneous use with antidiarrheal medications increases the risk of pseudomembranous colitis.
Concomitant use with opioid (narcotic) analgesics may increase the respiratory depression they cause (up to apnea).
Special Instructions
– Use in liver dysfunction: Clindamycin is used with caution in patients with severe hepatic impairment. Patients should monitor liver function (liver enzymes).
– Use in renal dysfunction: Clindamycin is used with caution in patients with severe renal failure.
Pseudomembranous colitis may appear both during treatment with clindamycin and 2-3 weeks after discontinuation of treatment (3-15% of cases); it is manifested with diarrhea, leukocytosis, fever, abdominal pain (sometimes accompanied with excretion of blood and mucus in feces).
In case of these phenomena in mild cases withdrawal of treatment and use of ion exchange resins (colestyramine, colestipol) is sufficient, in severe cases compensation of loss of fluids, electrolytes and protein and administration of oral vancomycin or metronidazole is indicated.
Do not use drugs that inhibit intestinal peristalsis.
The safety of the drug in children under 3 years of age has not been established. Periodic monitoring of blood count and liver function is necessary during long-term therapy in children.
When prescribing the drug in high doses it is necessary to monitor the plasma concentration of clindamycin.
Contraindications
– Myasthenia gravis.
– Bronchial asthma.
– Ulcerative colitis (history).
– Rare hereditary diseases, such as: galactose intolerance, lactase deficiency or glucose-galactose malabsorption (for capsules).
– Pregnancy.
– Period of lactation.
– Children under 8 years of age for capsules (average weight of the child is less than 25 kg).
– Hypersensitivity.
With caution is used in patients with:
– Severe hepatic and/or renal impairment.
– In elderly patients.
Overdose
– Symptoms: possible exacerbation of side effects.
– Treatment: symptomatic therapy, no specific antidote.
Hemodialysis and peritoneal dialysis are ineffective.
Pregnancy use
Contraindicated
Similarities
Weight | 0.018 kg |
---|---|
Shelf life | 3 years. |
Conditions of storage | Store at 15-25 °C. Keep out of reach of children. Do not use after the expiration date. |
Manufacturer | Chemopharm A.D., Serbia |
Medication form | capsules |
Brand | Chemopharm A.D. |
Other forms…
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