Citovir-3, 20 g

Pharmacotherapeutic group: immunostimulant

ATX code: L03AH

Pharmacological properties:

Pharmacodynamics:The drug is a means of etiotropic and immunostimulant therapy, has mediated antiviral action against the causative agents of influenza A and B, as well as other viruses causing acute respiratory diseases.

In in vitro studies the drug specifically suppresses (inhibits) multiplication (replication) of SARS-CoV-2 virus which is the causative agent of a new coronavirus infection (COVID-19).

The degree of inhibition of the pathogen increases with increasing drug concentration (dose-effect linearity is shown).

Limits the severity of the main clinical symptoms of influenza and acute respiratory infections, as well as reduces the duration of the disease and contributes to its uncomplicated course.

It increases the content of secretory immunoglobulin A (sIgA) in the nasopharynx mucosa, the entry gate of infection, increasing the local immunoresistance of the body to respiratory infections of viral and bacterial nature.

In case of preventive action the preparation increases potential metabolic activity of cells of innate immunity (neutrophil granulocytes and monocytes) which in case of development of infection increases their ability to absorb and destroy bacterial and viral agents due to increase of enzymatic (oxidative) activity, synthesis of cationic proteins and increase of the number of phagocytes. At the same time the initial state of the metabolic activity of cells of innate immunity, in the absence of infectious agents, does not change, being within normal values.

Bendazole induces in the body the production of endogenous interferon and has immunomodulatory effects (normalizes the immune response of the body). Enzymes produced by interferon in cells of various organs inhibit the replication of viruses.

Alpha-glutamyl-tryptophan (thymogen) is a synergist of immunomodulatory action of bendazole, normalizing the T-cell link of immunity.

Ascorbic acid activates the humoral part of the immune system, normalizes capillary permeability, thus reducing inflammation, and shows antioxidant properties, neutralizing the oxygen radicals that accompany the inflammatory process, increases the body’s resistance to infection.

Pharmacokinetics:when taken orally, the drug is completely absorbed from the gastrointestinal tract. Bioavailability of bendazole is about 80%, alpha-glutamyl-tryptophan – no more than 15%, ascorbic acid – up to 70%. Ascorbic acid is absorbed in the gastrointestinal tract (mainly in the jejunum). Binding with plasma proteins –
25%. TC_max after oral administration – 4 hours. It easily penetrates into leukocytes, platelets and then into all tissues, penetrates through the placenta.

Gastrointestinal diseases (gastric and 12 duodenal ulcer, bowel motility disorders, helminth infestation, giardiasis), consumption of vegetable and fruit juices, alkaline drinking reduce the binding of ascorbic acid in the intestine. Ascorbic acid is metabolized mainly in the liver to deoxyascorbic acid, then to oxalic acetic acid and diketogulonic acid. It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and as metabolites. The products of bendazole biotransformation in blood are two conjugates formed due to methylation and carboethoxylation of imino group of imidazole ring of bendazole: 1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2-benzylbenzimidazole. Bendazole metabolites are excreted in the urine. Alpha-glutamyl-tryptophan is cleaved by peptidases into L-glutamic acid and L-tryptophan, which are used by the body in protein synthesis.

Indications

Composition

1 ml of the prepared solution contains:
Active ingredients:
Alpha-glutamyl-tryptophan
(Timogen sodium in terms of thymogen) 0.15 mg
Ascorbic acid 12 mg
Bendazol hydrochloride [Dibazole] 1.25 mg
Excipients:
Lactose monohydrate 20 mg
In the preparation without flavoring:
Fructose 366.6 mg
In the preparation with flavoring:
Fructose 366.2 mg
Food flavoring
“Orange” or “Strawberry” or “Cranberry” 0.4 mg

How to take, the dosage

Ingestion 30 minutes before a meal.

For treatment:

For children aged 1 to 3 years, 2 ml 3 times a day; for children aged 3 to 6 years, 4 ml 3 times a day; for children aged 6 to 10 years, 8 ml 3 times a day; for children over 10 years, 12 ml 3 times a day.

The course of application is 4 days. If after 3 days of treatment there is no improvement, or the symptoms worsen, or new symptoms appear, it is necessary to consult a physician.

To prevent:

In direct contact with patients with influenza and other acute respiratory infections:

For children aged 1 to 3 years, 2 ml 3 times a day; for children aged 3 to 6 years, 4 ml 3 times a day; for children aged 6 to 10 years, 8 ml 3 times a day; for children over 10 years, 12 ml 3 times a day.

The course of application is 4 days.

Preventive courses, if necessary, should be repeated in 3 weeks (until normalization of the epidemic situation).

Rules for preparing the solution: In a bottle with powder add 40 ml of water (boiled, cooled to room temperature), shake well. The contents should dissolve completely. The volume of the solution after adding water is 50 ml.

Take the product only according to the route of administration and in the doses described in the instructions. If necessary, please talk to your doctor before taking this medicine.

Take only according to the directions given.

Interaction

Special Instructions

The drug contains fructose, use for more than 2 weeks may cause dental damage.

After repeated course it is recommended to control blood glucose concentration.

Information for diabetics: 1 ml of the solution of the drug contains 20 mg of lactose and 366.6 mg of fructose (in the unscented product or 366.2 mg of fructose in the flavored product), which corresponds to 0.032 bread units (BE).

The content of sugars in single and daily doses of the product, in units of units:

Ready solution, ml

Disposable dose, units

Daily dose, units

2

0.06

0.19

Synopsis

Contraindications

Hypersensitivity to the drug components, lactase deficiency, lactose intolerance, sugar/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, pregnancy, children under 1 year of age. If necessary, please consult a physician before taking the drug.

With caution:

Please consult your doctor before taking the drug if you have diabetes, intolerance to certain sugars, or arterial hypotension.

Side effects

Overdose

Pregnancy use