Cinnarizin Avexima, tablets 25 mg 50 pcs

• The drug blocks the passage of calcium ions through the cell membrane. This helps reduce their presence in the depot.
• The drug reduces tinnitus, reduces headaches. This occurs because the property of the drug to improve vascular health helps to normalize cerebral circulation.
• Tonus of the smooth muscles of the arterioles decreases. Peripheral and coronary circulation improves, tissues are supplied with blood more fully. Postischemic hyperemia is possible.
• Biogenic vasoconstrictors after taking the drug do not have an adequate response from the body, because cinnarizine is able to inhibit them. The property of cinnarizine to exhibit antihistamine activity in moderate quantities also works to improve blood circulation.
• The ingredients of the drug act on the blood cells, reducing the index of its viscosity. Erythrocytes under the influence of the product improve the condition of the membranes, increasing their elasticity. The product helps cells to survive in conditions of oxygen deficiency.

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Indications

– vestibular disorders (including.ч. Meniere’s disease: vertigo, tinnitus, nystagmus, nausea and vomiting of labyrinthine origin);

– prevention of kinetosis (“road sickness” – sea and air sickness);

– migraine (seizure prevention);

– peripheral circulatory disorders: Raynaud’s disease, intermittent claudication, acrocyanosis, trophic disorders (including.including trophic and varicose ulcers).

Active ingredient

Composition

Active ingredient:

25 mg cinnarizine

Additional ingredients:

How to take, the dosage

Ingestion, after meals.

In case of insufficiency of cerebral circulation, 25 mg 3 times a day.

In case of peripheral circulation failure – 50-75 mg 3 times/day.

In vestibular disorders, 25 mg 3 times/day.

The maximum recommended dose should not exceed 225 mg (9 tablets) daily. The course of treatment can be from several weeks to several months.

In kinetosis (“road” disease): adults, 25 mg half an hour before travel (repeat 25 mg 6 hours later if necessary), for children from 5 years of age, 1/2 the dose recommended for adults.

In case of high sensitivity to the drug, treatment begins with 1/2 dose, increasing it gradually.

Interaction

It potentiates CNS depressant effect of alcohol, sedatives, tricyclic antidepressants. Due to the presence of antihistamine effect, cinnarizine may affect the result of anti-doping control of athletes (false positive result), and can negate the positive reactions during skin diagnostic tests (4 days before the study the treatment should be canceled).

Special Instructions

Parkinson’s disease patients are prescribed the drug only if the benefits of treatment with cinnarizine are greater than the possible worsening of the underlying disease.

In the beginning of treatment it may cause somnolence, therefore caution should be exercised when taking alcohol and concomitant use of CNS depressants.

Because of the antihistamine effect, administration of cinnarizine should be discontinued 4 days before allergic skin testing. Cinnarizine may affect the result in anti-doping controls of athletes (false positive result).

In case of lactose intolerance, note that 1 tablet contains 175 mg of lactose.

Impact on ability to drive and other working mechanisms

Drowsiness may develop, especially at the beginning of treatment; therefore, caution should be taken when driving motor transport and engaging in other potentially dangerous activities requiring increased concentration and rapid psychomotor reactions. During long-term use it is recommended to perform control laboratory examination of liver and renal function and peripheral blood.

Contraindications

– hypersensitivity;

– pregnancy;

– lactation period;

– children under 5 years of age.

With caution in Parkinson’s disease.

Side effects

Nervous system disorders: drowsiness, fatigue, headache, extrapyramidal disorders (limb tremor and increased muscle tone, hypokinesia), depression.

Digestive system disorders: dry mouth, epigastric pain, dyspepsia, cholestatic jaundice.

Skin disorders: sweating, development of lupus-like syndrome, lichen planus (extremely rare), skin rash.

Others: allergic reactions, weight gain.

Overdose

Symptoms: increased severity of side effects, decreased BP, vomiting, coma.

Treatment: there is no specific antidote, gastric lavage, activated charcoal, symptomatic therapy.

Similarities