Cereton, 250 mg/ml 4 ml 3 pcs

Pharmacodynamics

Cereton provides synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation.

It increases linear velocity of blood flow on the side of the traumatic brain injury, promotes normalization of spontaneous bioelectrical activity of the brain, regress of focal neurological symptoms and restoration of consciousness; it has a positive effect on cognitive and behavioral responses of patients with cerebral vascular diseases (discirculatory encephalopathy and residual effects of brain circulation disorders). Stimulates dose-dependent release of acetylcholine under physiological conditions, improves synaptic transmission and receptor function. It does not influence the reproductive cycle and has no teratogenic and mutagenic action.

It has preventive and corrective action on pathogenetic factors of involutional psychoorganic syndrome, changes the phospholipid composition of neuronal membranes: participates in the synthesis of phosphatidylcholine (membrane phospholipid) and improves neuronal membrane plasticity.

Pharmacokinetics

When administered parenterally (10 mg/kg) Cereton mainly accumulates in the brain, lungs and liver. Absorption is 88%, easily penetrates through the blood-brain barrier (when administered orally, the concentration in the brain is 45% of that in plasma). The lungs excrete 85% of the drug as carbon dioxide, the remaining amount (15%) is excreted by the kidneys and through the intestines.

Indications

Acute and recovery periods of severe CMP and ischemic stroke, recovery period of hemorrhagic stroke with focal hemispheric symptoms or symptoms of brainstem involvement;

Active ingredient

Composition

1 ml contains:

active ingredient:

glycerylphosphorylcholine hydrate 250 mg,

excipients:

water for injection

How to take, the dosage

In acute conditions, the solution is administered intravenously (slowly) or deeply intramuscularly at 1000 mg (1 ampoule) per day for 10-15 days.

Interaction

Significant interactions with other drugs have not been found.

Special Instructions

Cereton has no effect on the speed of psychomotor reactions.

Contraindications

Side effects

Nausea may occur (mainly as a consequence of dopaminergic activation), in which case the drug dose should be reduced.

In the digestive system: constipation, diarrhea, dry mucous membrane of the mouth, pharyngitis.

Nervous system disorders: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, cerebral ischemia, seizures, dizziness.

Skin disorders: rash, urticaria.

Others: pain at the site of injection, increased frequency of urination.

Allergic reactions.

Overdose

Symptoms: nausea may occur.

Treatment: symptomatic therapy.

Pregnancy use

It is contraindicated during pregnancy and lactation.

Similarities