Ceresil Canon, 250 mg/ml 4 ml 5 pcs

Pharmacodynamics

Cyticoline is a natural endogenous compound which is an intermediate metabolite in the synthesis of phosphatidylcholine, one of the main structural components of the cell membrane. Citicoline, being a precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a broad spectrum of action: it promotes the restoration of damaged cell membranes, inhibits the action of phospholipases, prevents the excessive formation of free radicals and also prevents cell death by acting on apoptosis mechanisms. In the acute period of stroke citicoline reduces the volume of brain tissue damage, improves cholinergic transmission. In craniocerebral trauma reduces the duration of post-traumatic coma and severity of neurological symptoms, in addition, contributes to reducing the duration of the recovery period. In chronic cerebral hypoxia citicoline is effective in treating cognitive disorders such as memory impairment, lack of initiative, difficulties in daily activities and self-care. It increases the level of attention and consciousness and reduces the manifestation of amnesia.

Cyticoline is effective in the treatment of sensory and motor neurological disorders of degenerative and vascular etiology.

Pharmacokinetics

absorption

Cyticoline is well absorbed when taken orally. Absorption after oral administration is almost complete and bioavailability is about the same as after intravenous administration.

Distribution

Cyticoline is largely distributed in brain structures, with rapid incorporation of choline fractions into structural phospholipids and citidine fractions into citidine nucleotides and nucleic acids.

Cyticolin penetrates the brain and is actively incorporated into cellular, cytoplasmic and mitochondrial membranes, forming part of the structural phospholipid fraction.

Metabolism

The drug is metabolized in the intestine and in the liver to form choline and cytidine. After intake, plasma concentrations of choline are significantly increased.

Evacuation

Only 15% of the administered dose of citicoline is excreted from the human body: less than 3% by the kidneys and through the intestines and about 12% with exhaled CO2.

Two phases can be distinguished in the urinary excretion of citicoline: a first phase lasting about 36 hours, during which the excretion rate decreases rapidly, and a second phase, during which the excretion rate decreases much more slowly. The same is observed in exhaled CC2 – the excretion rate decreases rapidly after about 15 hours and then decreases at a much slower rate.

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Indications

Active ingredient

Composition

How to take, the dosage

Ceresil® Canon oral solution is administered orally. Before use, the drug may be diluted in a small amount of water (100-120 ml or ½ cup).

Take with meals or between meals.

Recommended dosage regimen

Acute period of ischemic stroke and traumatic brain injury (TBI): 1000 mg (10 ml) every 12 h from the first day after diagnosis, treatment duration at least 6 weeks.

Restorative period of ischemic and hemorrhagic strokes, the restorative period of CHT, cognitive and behavioral disorders in degenerative and vascular brain diseases: 500-2000 mg per day (5-10 ml 1-2 times a day). Dosage and duration of treatment depending on the severity of the symptoms of the disease.

Interaction

Citicoline enhances the effects of levodopa.

Do not use simultaneously with drugs containing meclofenoxate.

Special Instructions

Small amounts of crystals may form in the cold due to temporary partial crystallization of the preservative. Upon further storage under recommended conditions the crystals dissolve within several months. The presence of crystals does not affect the quality of the product.

Influence on the ability to drive vehicles and mechanisms

During treatment, caution should be exercised when performing potentially hazardous activities requiring particular attention and quick reactions (driving a car and other vehicles, working with moving machinery, work of dispatcher and operator, etc.).

Contraindications

Side effects

From the digestive system: Nausea, decreased appetite, changes in liver enzyme activity.

Allergic reactions:rash, skin itching, anaphylactic shock.

Others: fever; in some cases, short-term hypotensive effect, stimulation of the parasympathetic nervous system.

Overdose

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