Celebrex, 400 mg+200 mg capsules 1+5 pcs

Celecoxib has anti-inflammatory, analgesic and antipyretic effects by blocking the formation of inflammatory prostaglandins (Pg) mainly by inhibiting cyclooxygenase-2 (COX-2). Induction of COX-2 occurs in response to inflammation and leads to the synthesis and accumulation of prostaglandins, especially prostaglandin E₂, with increased manifestations of inflammation (edema and pain). In human therapeutic doses, celecoxib does not significantly inhibit cyclooxygenase-1 (COX-1) and has no effect on prostaglandins synthesized as a result of COX-1 activation, and does not affect normal physiological processes connected with COX-1 and running in tissues, especially in stomach, intestine and platelet tissues.

The effect on renal function

Celecoxib reduces urinary excretion of PgE₂ and 6-keto-PgF₁(prostacyclin metabolite), but has no effect on serum thromboxane B₂ and urinary excretion of 11-dehydro-thromboxane B₂, a metabolite of thromboxane (both COX-1 products). Celecoxib does not cause decreased glomerular filtration rate (GFR) in elderly patients and those with chronic renal insufficiency, transiently decreases sodium excretion. In patients with arthritis, the observed incidence of peripheral edema, arterial hypertension and heart failure is comparable to that of non-selective COX inhibitors, which have inhibitory activity against COX-1 and COX-2. This effect was most pronounced in patients treated with diuretics. However, there was no increase in the incidence of BP and heart failure, and peripheral edema was mild and resolved spontaneously.

Indications

Active ingredient

Composition

1 capsule contains:

The active ingredient: celecoxib

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Similarities