Caposide, tablets 50 mg + 25 mg 28 pcs.
€20.19 €16.83
Captopril® is a combined drug with hypotensive and diuretic effects.
Captopril is an angiotensin-converting enzyme (ACE) inhibitor, reduces angiotensin II formation from angiotensin I, decreases aldosterone release, reduces total peripheral vascular resistance (TPR), blood pressure (BP), post- and preload. It dilates arteries more than veins.
It enhances coronary and renal blood flow. Long-term use reduces myocardial hypertrophy and arterial wall resistance. Captopril improves blood supply to ischemic myocardium; reduces platelet aggregation.
Hydrochlorothiazide is a thiazide diuretic of medium strength, reduces sodium ion reabsorption at the level of the cortical segment of the Genle loop. It does not affect acid-base status (COS). Lowers BP by changing the reactivity of the vascular wall, reducing the pressor effect of endogenous vasoconstrictors (adrenaline, noradrenaline) and increasing the depressor effect on the autonomic ganglia (to a lesser extent, by reducing circulating blood volume (CBV)). It enhances the hypotensive effect of captopril.
Diuretic effect is noted after 2 hours and reaches a maximum of 4 hours after oral administration. The action lasts for 6-12 hours. Efficacy and safety of captopril in children have not been established. Limited experience with captopril in children has been described in the literature.
Children, especially newborns, may be more susceptible to the development of hemodynamic side effects. Cases of excessive, prolonged and unpredictable increases in blood pressure, as well as related complications, including oliguria and seizures, have been reported.
Indications
Arterial hypertension (patients who are indicated for combination therapy)
Active ingredient
Hydrochlorothiazide, Captopril
Composition
One tablet contains:
active ingredients:
- captopril in terms of 100% substance – 50 mg, hydrochlorothiazide in terms of 100% substance – 25 mg;
excipients:
- cellulose microcrystalline – 118.5 mg,
- pregelatinized starch (corn) – 30 mg, <
- stearic acid – 6 mg,
- magnesium stearate – 0.3 mg,
- lactose monohydrate – 70.2 mg.
.
How to take, the dosage
Caposide is taken orally, regardless of meals.
Start with 1/2 tablet, increasing the dose to 1 tablet once daily (maintenance dose).
Interaction
Increases neurotoxicity of salicylates, the effect of muscle relaxants of the competitive type of action, ethanol. Reduces excretion of quinidine, the effect of oral hypoglycemic drugs (drugs), norepinephrine, epinephrine and antipodagric drugs.
Aggravates side effects of cardiac glycosides, especially when combined with drugs that increase excretion of potassium and magnesium ions and/or retain calcium ions (e.g. diuretics, adrenal hormones, laxatives, amphotericin B, carbenoxolone, penicillin G, salicylates). Cimetidine, by slowing down the metabolism of captopril in the liver, increases its plasma concentration.
Special Instructions
An excessive decrease in blood pressure may be observed at the beginning of treatment, especially in patients with chronic heart failure, severe arterial hypertension (including renal genesis) and/or renal insufficiency.
Before starting treatment, it is necessary to compensate for sodium ion deficiency and BOD (decrease the dose of previously prescribed diuretics or, in some cases, cancel them completely), as well as to determine renal function parameters.
Potential plasma concentrations of potassium and calcium ions should be monitored regularly (especially in patients treated with foxgloves, glucocorticosteroids (GCS), frequent laxatives, and elderly patients), glucose, uric acid, lipids (cholesterol and triglycerides (TG)), urea and creatinine, activity of “liver” enzymes.
Particular close monitoring of BP and laboratory values is necessary in the following cases: patients with renal insufficiency; patients with severe arterial hypertension (including of renal genesis); elderly patients (older than 65 years); patients with water-electrolyte balance disorders and decompensated CHF; as well as patients simultaneously receiving allopurinol, lithium salts, procainamide and drugs that reduce immunity.
In case of fever, enlarged lymph nodes and/or signs of laryngitis and/or pharyngitis, the leukocyte count should be determined immediately.
During treatment, caution should be exercised when driving motor vehicles and engaging in other potentially hazardous activities that require increased concentration and quick psychomotor reactions.
Contraindications
- High sensitivity to captopril, any other component of the drug or other ACE inhibitors, thiazide diuretics and other sulfonamide derivatives (cross-allergic reactions possible);
- hereditary or idiopathic angioedema, including a history of ACE inhibitors;
- aortic stenosis,
- mitral stenosis;
- hypertrophic obstructive cardiomyopathy;
- Kidney transplantation (history);
- chronic heart failure;
- cardiogenic shock,
- arterial hypotension,
- severe hepatic failure (precoma or coma);
- severe renal insufficiency (serum creatinine greater than 1.8 mg/100 ml or creatinine clearance less than 20-30 ml/min, anuria);
- Primary hyperaldosteronism;
- concomitant use with aliskiren and aliskiren-containing drugs in patients with diabetes mellitus or impaired renal function (FFR less than 60 mL/min),
- pregnancy,
- age less than 18 years (efficacy and safety not established),
- lactose intolerance, lactase deficiency and glucose-galactose malabsorption syndrome.
With caution
– Liver function disorders, advanced liver disease,
– moderate renal insufficiency (creatinine clearance 30-60 ml/min),
– proteinuria (more than 1 g/day),
– Hypokalemia (not corrected by medicines);
– hyponatremia,
– hypovolemia,
– hypercalcemia,
– gout, hyperuricemia,
– systemic connective tissue diseases and other autoimmune diseases (including those of the following groups).ч. The following conditions should be observed:
– elderly (over 65 years),
– simultaneous prescription of medications that suppress the body’s defense reactions (glucocorticosteroids, cytostatics, immunosuppressants), allopurinol, procainamide;
– surgery/common anemia. – surgery/general anesthesia, use in non-HGM patients, hemodialysis using high-strength membranes (e.g., AN69®), desensitization therapy, simultaneous use of potassium-saving diuretics, potassium preparations, potassium substitutes and lithium, acute myopia and secondary closed-angle glaucoma.
Side effects
Urinary system disorders: proteinuria; in rare cases, especially in patients with renal failure, increased serum concentrations of urea, creatinine and potassium ions may be noted (the risk of hyperkalemia is also increased in diabetic patients), as well as hyponatremia.
Overdose
The severity of side effects may increase.
Treatment: symptomatic therapy.
Weight | 0.020 kg |
---|---|
Shelf life | 3 years. |
Conditions of storage | The drug should be stored in a dry place protected from light, out of reach of children, at a temperature not exceeding 20 ° C. |
Manufacturer | Akrihin HFC JSC, Russia |
Medication form | pills |
Brand | Akrihin HFC JSC |
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