Caposide, tablets 50 mg + 25 mg 28 pcs.

Captopril® is a combined drug with hypotensive and diuretic effects.

Captopril is an angiotensin-converting enzyme (ACE) inhibitor, reduces angiotensin II formation from angiotensin I, decreases aldosterone release, reduces total peripheral vascular resistance (TPR), blood pressure (BP), post- and preload. It dilates arteries more than veins.

It enhances coronary and renal blood flow. Long-term use reduces myocardial hypertrophy and arterial wall resistance. Captopril improves blood supply to ischemic myocardium; reduces platelet aggregation.

Hydrochlorothiazide is a thiazide diuretic of medium strength, reduces sodium ion reabsorption at the level of the cortical segment of the Genle loop. It does not affect acid-base status (COS). Lowers BP by changing the reactivity of the vascular wall, reducing the pressor effect of endogenous vasoconstrictors (adrenaline, noradrenaline) and increasing the depressor effect on the autonomic ganglia (to a lesser extent, by reducing circulating blood volume (CBV)). It enhances the hypotensive effect of captopril.

Diuretic effect is noted after 2 hours and reaches a maximum of 4 hours after oral administration. The action lasts for 6-12 hours. Efficacy and safety of captopril in children have not been established. Limited experience with captopril in children has been described in the literature.

Children, especially newborns, may be more susceptible to the development of hemodynamic side effects. Cases of excessive, prolonged and unpredictable increases in blood pressure, as well as related complications, including oliguria and seizures, have been reported.

Indications

Arterial hypertension (patients who are indicated for combination therapy)

Active ingredient

Composition

One tablet contains:

How to take, the dosage

Caposide is taken orally, regardless of meals.

Start with 1/2 tablet, increasing the dose to 1 tablet once daily (maintenance dose).

Interaction

Special Instructions

An excessive decrease in blood pressure may be observed at the beginning of treatment, especially in patients with chronic heart failure, severe arterial hypertension (including renal genesis) and/or renal insufficiency.

Before starting treatment, it is necessary to compensate for sodium ion deficiency and BOD (decrease the dose of previously prescribed diuretics or, in some cases, cancel them completely), as well as to determine renal function parameters.

Potential plasma concentrations of potassium and calcium ions should be monitored regularly (especially in patients treated with foxgloves, glucocorticosteroids (GCS), frequent laxatives, and elderly patients), glucose, uric acid, lipids (cholesterol and triglycerides (TG)), urea and creatinine, activity of “liver” enzymes.

Particular close monitoring of BP and laboratory values is necessary in the following cases: patients with renal insufficiency; patients with severe arterial hypertension (including of renal genesis); elderly patients (older than 65 years); patients with water-electrolyte balance disorders and decompensated CHF; as well as patients simultaneously receiving allopurinol, lithium salts, procainamide and drugs that reduce immunity.

In case of fever, enlarged lymph nodes and/or signs of laryngitis and/or pharyngitis, the leukocyte count should be determined immediately.

During treatment, caution should be exercised when driving motor vehicles and engaging in other potentially hazardous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Side effects

Overdose

The severity of side effects may increase.

Treatment: symptomatic therapy.