Canizon Plus, cream 15 g

Canisone plus is a combined drug with anti-inflammatory, anti-allergic, antibacterial and antifungal (fungicidal) effects.

Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides, it acts bactericidally. Gram-negative microorganisms – Proteus spp. (indole-positive and indole-negative), Escherichia coli, Klebsiella spp. Salmonella spp., Shigella spp., Campylobacter spp. Staphylococcus spp. (methicillin-resistant).

Sensitive: Enterococcus faecalis, Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp.

Resistant: Neisseria meningitidis, Treponema pallidum, anaerobic microbes: Streptococcus spp. (except Streptococcus pneumoniae), Enterococcus faecalis; Providencia rettgeri.

Betamethasone is a glucocorticosteroid, has a local anti-inflammatory, vasoconstrictor, anti-allergic effect.

Clotrimazole is an antifungal agent from the group of imidazole derivatives for topical use. It acts by disrupting the synthesis of ergosterol, which is a part of the cell membrane of fungi. It has a wide spectrum of action. It is effective against dermatophytes, mold fungi, fungi of the genus Candida, Malassezia furfur, Corynebacterium minutissimum, Streptococcus spp, Staphylococcus spp, Trichomonas vaginalis.

Indications

simple and allergic dermatitis (complicated by secondary infection);
atopic dermatitis (including diffuse neurodermatitis);
eczema;
dermatomycosis (dermatophytosis, candidiasis, lichen versicolor), especially when localized in the groin area and large folds of the skin;
simple chronic lichen (limited neurodermatitis).

Pharmacological effect

Kanizon Plus is a combined drug that has anti-inflammatory, antiallergic, antibacterial and antifungal (fungicidal) effects.

Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides that has a bactericidal effect. Highly sensitive gram-negative microorganisms – Proteus spp. (indole-positive and indole-negative), Escherichia coli, Klebsiella spp.. Salmonella spp., Shigella spp., Campylobacter spp.. Staphylococcus spp. (methicillin-resistant).

Sensitive: Enterococcus faecalis, Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp.

Resistant: Neisseria meningitidis, Treponema pallidum, anaerobic microbes: Streptococcus spp. (except Streptococcus pneumoniae), Enterococcus faecalis; Providencia rettgeri.

Betamethasone is a glucocorticosteroid that has local anti-inflammatory, vasoconstrictor, and antiallergic effects.

Clotrimazole is an antifungal agent from the group of imidazole derivatives for topical use. It has an effect by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Has a wide spectrum of action. Effective against dermatophytes, molds, fungi of the genus Candida, Malassezia furfur, Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas vaginalis.

Special instructions

Kanizon Plus cream is not intended for use in ophthalmology. Avoid getting the cream into your eyes.

Prolonged local use of antibiotics can sometimes lead to the growth of resistant microflora. In this case, as well as with the development of irritation, sensitization or superinfection during treatment with Kanizon Plus cream, treatment should be stopped and appropriate therapy should be prescribed. Cross-allergic reactions with aminoglycoside antibiotics have been observed.

Any side effects encountered with the use of systemic glucocorticosteroids, including suppression of adrenal function, may also occur with topical use of glucocorticosteroids, especially in children.

Systemic absorption of glucocorticosteroids or gentamicin when applied topically will be higher if treatment is carried out over large areas of skin or when using occlusive dressings, especially during long-term treatment or when the integrity of the skin is compromised. Avoid applying gentamicin to open wounds and damaged skin. Otherwise, side effects characteristic of gentamicin when used systemically may occur. Appropriate precautions should be taken in such cases, especially when treating children. With long-term use of the drug, it is recommended to discontinue it gradually.

Active ingredient

Betamethasone, Gentamicin, Clotrimazole

Composition

1 g of cream for external use contains:

active ingredients:

betamethasone dipropionate 640 mcg,

clotrimazole 10 mg,

gentamicin sulfate 1 mg

Pregnancy

The use of the drug in the first trimester of pregnancy is not recommended. Clinical and experimental studies have not found that the use of clotrimazole during pregnancy has a negative effect on the health of the woman and the fetus.

However, the question of the advisability of prescribing the drug in the second and third trimesters of pregnancy should be decided individually after consulting a doctor. The possibility of excretion of clotrimazole in breast milk has not been studied. Therefore, Kanizon Plus, cream for external use should be used with caution in nursing mothers.

The drug is prescribed to children only according to strict indications and under medical supervision, because Systemic side effects associated with betamethasone may develop.

When using Canizon Plus cream, like many other drugs for topical use based on glucocorticosteroids, on large surfaces and/or with an occlusive dressing, suppression of the function of the hypothalamic-pituitary-adrenal system may be suppressed, a decrease in the excretion of growth hormone, as well as an increase in intracranial pressure may be observed.

Contraindications

lupus;
skin manifestations of syphilis;
chicken pox;
herpes simplex;
skin post-vaccination reactions;
open wounds;
children under 2 years of age;
indications of a history of hypersensitivity reactions to any of its components.

With caution: pregnancy (first trimester), long-term treatment, use on large areas of skin or when the integrity of the skin is damaged, use of occlusive dressings (especially in children).

Side Effects

Very rarely, when using Kanizon Plus cream, the following symptoms are observed: burning sensation, erythema, exudation, pigmentation disorders and itching.

Adverse reactions encountered when using local glucocorticosteroids (especially when using occlusive dressings): burning sensation, itching, dry skin, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, development of secondary infection, skin atrophy, stretch marks, prickly heat.

Adverse reactions caused by clotrimazole: erythema, tingling sensation, blistering, peeling, local swelling, itching, urticaria, skin irritation.

Adverse reactions caused by gentamicin: transient skin irritation (erythema, itching), which usually does not require discontinuation of treatment.

Interaction

When Canizon Plus is used simultaneously with antifungal drugs of other groups, the effectiveness of these drugs used externally decreases.

The use of gentamicin may result in excessive growth of non-susceptible (highly resistant) microorganisms, including fungi.

If superinfection occurs during a therapeutic course of treatment with gentamicin, the drug should be discontinued and a course of appropriate therapy should be prescribed.

Overdose

Symptoms: with long-term use of local glucocorticosteroids in high doses, suppression of adrenal function with the development of secondary adrenal insufficiency and symptoms of hypercortisolism, including Cushing’s syndrome, is possible.

An overdose of clotrimazole when applied topically does not lead to the appearance of any symptoms.

With a single overdose of gentamicin, the appearance of any symptoms is also not expected.

Long-term treatment with gentamicin in high doses can lead to the growth of insensitive flora.

Treatment: symptomatic. Acute symptoms of hypercortisolism are usually reversible. If necessary, electrolyte imbalance is corrected. In case of chronic glucocorticosteroid toxicity, gradual withdrawal of glucocorticosteroids is recommended.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Manufacturer

Agio Pharmaceuticals Ltd, India