Calcium gluconate-SOLOPHARM, 100 mg/ml 5 ml 10 pcs

Indications

Treatment of acute hypocalcemia.

Pharmacological effect

Pharmacotherapeutic group

Calcium-phosphorus metabolism regulator.

ATX code: A12AA03

Pharmacological properties

Pharmacodynamics

The calcium supplement replenishes the deficiency of calcium ions necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone tissue formation, and blood clotting.

When administered intravenously, it stimulates the sympathetic part of the autonomic nervous system and enhances the release of adrenaline by the adrenal glands.

Pharmacokinetics

After parenteral administration of calcium gluconate is distributed evenly through the bloodstream in all tissues and organs. In blood plasma, calcium is found both in bound form (in complex with proteins and with anions of organic and inorganic acids (bicarbonate, phosphate, lactate, calcium citrate)) and in free ionized form. Penetrates the placental barrier and enters breast milk. It is excreted from the body mainly by the kidneys.

Special instructions

The drug is heated to body temperature before administration. The drug is administered deeply intramuscularly or intravenously slowly (over 2-3 minutes), or by drip, to eliminate the possibility of local irritation or necrosis if the drug gets into perivascular tissue. Intravenous injections should be carried out under close monitoring of heart rate and electrocardiogram, since bradycardia with vasodilation and arrhythmias may occur if calcium gluconate is administered too quickly.

Active ingredient

Calcium gluconate

Composition

1 ml of the drug contains:

Active ingredient:

Calcium gluconate monohydrate 94 mg

Excipients:

Calcium saccharate 5 mg

Water for injections up to 1 ml

Contraindications

Hypersensitivity to calcium gluconate and other components of the drug, hypercalcemia (including in patients with hyperparathyroidism, hypervitaminosis D, decalcifying malignant neoplasms, renal failure, osteoporosis associated with immobilization, sarcoidosis, milk-alkali syndrome (Burnett’s syndrome)), hypercalciuria, intoxication with cardiac glycosides, simultaneous treatment with cardiac glycosides; for intramuscular administration – children’s age.

With caution

Dehydration, electrolyte disturbances (risk of developing hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (history), slight hypercalciuria, moderate chronic renal failure, widespread atherosclerosis, hypercoagulation, in elderly patients, especially in the presence of one or more of the above conditions, nephrocalcinosis, pathology of the cardiovascular system, sarcoidosis, chronic heart failure, simultaneous treatment with epinephrine. Before using the drug, you should consult your doctor.

Side Effects

The incidence of side effects is directly related to the rate of administration and dose of calcium gluconate. When administered correctly, the frequency of their occurrence is 1/1000.

Interaction

The syringe filled with a solution of calcium gluconate should not contain residues of ethyl alcohol, since in the presence of calcium gluconate, the gluconate precipitates. Pharmaceutically incompatible with carbonates, salicylates, sulfates and ceftriaxone (forms insoluble or sparingly soluble calcium salts with them). Forms insoluble complexes with tetracycline antibiotics, reducing the antibacterial effect.

Overdose

Symptoms of hypercalcemia: anorexia, nausea, vomiting, constipation, abdominal pain, polyuria, polydipsia, dehydration, muscle weakness, bone pain, kidney calcification, drowsiness, hypersomnia, confusion, increased blood pressure, in severe cases – arrhythmia (up to cardiac arrest) and coma.

Storage conditions

Store at a temperature not exceeding 25 °C.

Shelf life

3 years.

Manufacturer

Grotex LLC, Russia