Calcium-D3 Nicomed forte lemon, 120 pcs.

Pharmacodynamics

It regulates calcium and phosphorus metabolism in the body (bones, teeth, nails, hair, muscles). It reduces resorption (resorption) and increases bone density, filling the lack of calcium and vitamin D3 in the body and is necessary for the mineralization of teeth.

Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood clotting system.

Vitamin D3 increases the absorption of calcium in the intestine.

The use of calcium and vitamin D3 inhibits increased production of parathyroid hormone (PTH), which is a stimulant of increased bone resorption (leaching of calcium from bones).

Pharmacokinetics

Calcium

absorption. Normally, the amount of calcium absorbed in the gastrointestinal tract is about 30% of the dose taken.

Distribution and metabolism. 99% of calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is in intra- and extracellular fluids.

About 50% of the total calcium in the blood is in the physiologically active ionized form, of which about 10% is complexed with citrate, phosphate or other anions; the remaining 40% is associated with proteins, primarily with albumin.

Elimination. Calcium is excreted by the intestines, kidneys, and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Vitamin D3

Intake.Vitamin D3 is readily absorbed in the small intestine (about 80% of the dose taken).

Distribution and metabolism. Coleciferol and its metabolites circulate in the blood, bound to specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycolecalciferol. It is then converted in the kidneys to the active form 1,25-hydroxycolecalciferol. 1,25-hydroxycalciferol is the metabolite responsible for increasing calcium absorption. Unmetabolized vitamin D3 is deposited in fat and muscle tissue.

Elimination. Vitamin D3 is excreted by the intestine and kidneys.

Indications

Active ingredient

Composition

1 tablet contains:

Calcium carbonate 1250 mg (corresponds to 500 mg of calcium)

Colecalciferol (vitamin D3) 400 IU

Associates:

Sorbitol

Isomalt

Povidone

Magnesium stearate

Aspartame

Lemon oil

Mono- and diglycerides of fatty acids.

How to take, the dosage

Tablets Calcium-D3 Nicomed forte is taken orally, chewed or chewed up, with meals.

The treatment of osteoporosis: adults – 1 tablet 2 times a day; in the treatment of osteoporosis – 1 tablet 2-3 times a day.

In case of calcium and vitamin D deficiency: adults and children over 12 years old – 1 tablet 2 times a day; children from 3 to 12 years old – 1 tablet a day.

Contraindications

With caution: pregnancy; period of lactation.

Side effects

Pregnancy use

The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.

Hypercalcemia from an overdose during pregnancy can cause mental and physical developmental defects in the child.

Vitamin D and its metabolites can pass into breast milk, so the intake of calcium and vitamin D from other sources in the mother and baby must be considered.

Similarities