Calcemin Advance, 60 pcs.

A combined product containing vitamins, micro- and macro-nutrients.

The action is due to the properties of the constituent ingredients.

Indications

Prevention and complex treatment of osteoporosis of different genesis:

– in women during menopause (natural and surgical);
– in persons who have been taking GCS and immunosuppressants.

Therapy of musculoskeletal system disorders (to improve the consolidation of traumatic fractures)
To compensate the deficiency of calcium and trace elements in adolescents.

Composition

Active ingredients:

calcium (calcium citrate and calcium carbonate) 500 mg,

colocalciferol (vitamin D3) 200 IU,

Magnesium 40 mg,

Zinc 7.5 mg,

Copper 1 mg,

Manganese 1.8 mg,

Boron 250 µg.

Auxiliary substances:

maltodextrin 25 mg,
microcrystalline cellulose 49, 05 mg,

croscarmellose sodium 38 mg,

stearic acid 16, 3 mg,

soy polysaccharide 15 mg,

sodium lauryl sulfate 5 mg.

The shell:

hypromellose 26, 328 mg,

titanium dioxide 12, 643 mg,

magnesium silicate 5 mg,

triacetin 5, 689 mg,

mineral oil 2, 845 mg,

p> dye red #40 (dye red charming) 0, 316,

dye yellow #6 (sunset yellow) 0, 079 mg,

dye blue #1 0, 04 mg.

Description:

The tablets are biconvex oval-shaped, coated with a pink coating with a rib on one side.

How to take, the dosage

Take orally, with meals.

The complex therapy of osteoporosis – 1 tablet 2 times a day.

Prevention of osteoporosis – 1 tablet a day.

When taking the preparation for prophylaxis and in complex therapy of osteoporosis the duration of treatment is determined by the doctor individually. Average course duration for prophylaxis is 2 months and for treatment of osteoporosis – 3 months.

Therapy of musculoskeletal system disorders: to improve the consolidation of traumatic fractures – 1 tablet a day, the duration of treatment is 4-6 weeks.

To replenish calcium and trace elements deficiency in adolescents from 12 years of age – 1 tablet a day. The average duration of treatment is 4-6 weeks.

Interaction

The toxicity of vitamin D3 is reduced when concomitant use of Calcemin with vitamin A. Phenytoin, barbiturates, GCS reduce the effectiveness of vitamin D3.

Laxatives decrease absorption of vitamin D3. GCS, hormonal contraceptives for systemic use, levothyroxine impair absorption of calcium ions. When coadministration of tetracyclines interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is impaired) – at least 2 hours. Calcemin drug co-administration with cardiac glycosides increases their toxicity (ECG and clinical state control is necessary), with thiazide diuretics – the risk of hypercalcaemia increases, with furosemide and other loop diuretics – renal calcium excretion increases.

Calcemin should not be used simultaneously with calcium channel blockers. It is not recommended to use the preparation in combination with antacids containing aluminum due to decrease of their effectiveness.

Special Instructions

The dose should not exceed the one indicated in the instructions because increased calcium intake may inhibit intestinal absorption of iron, zinc, and other essential minerals.

Impact on the ability to drive vehicles and operate machinery. There are no data on the effect of the drug on the speed of psychomotor reactions when driving and operating precise mechanisms.

Synopsis

Contraindications

Individual hypersensitivity to the drug components, hypervitaminosis of vitamin D, hypercalcemia and hypercalciuria, severe renal failure, urolithiasis, active tuberculosis, sarcoidosis, children (under 12 years), allergic reactions to peanut oil and soy, since the drug contains soy polysaccharide.

With caution:

Pregnancy and lactation period, renal failure.

Overdose

Vitamin D hypervitaminosis, hypercalcemia and hypercalciuria.

Symptoms: decreased appetite, thirst, polyuria, dizziness, fainting, constipation, nausea and vomiting, muscle weakness, headache, coma, increased fatigue, bone pain, mental disorders, nephrocalcinosis, abdominal pain, urolithiasis, in severe cases – cardiac arrhythmias.

In prolonged use in doses over 2500 mg of calcium – kidney damage, soft tissue calcinosis.

If the first signs of overdose are detected, reduce the dose or stop using the drug and seek medical attention.

In case of hypercalciuria greater than 7.5 mmol/d (300 mg/d), the dose should be reduced or the drug stopped.

Treatment: rehydration, use of loop diuretics (e.g., furosemide), glucocorticosteroids, calcitonin, bisphosphonates, in severe cases hemodialysis.

In case of accidental overdose it is necessary to induce vomiting, gastric lavage. Therapy is symptomatic.

The dose should be reduced or the drug should be discontinued. In case of accidental overdose, vomiting and gastric lavage should be induced. Therapy is symptomatic.

Pregnancy use

During pregnancy and breast-feeding the drug administration should be coordinated with the doctor.

The fixed dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3; hypergallcemia caused by overdose during pregnancy can cause defects in the mental and physical development of the fetus.

In breastfeeding women it should be taken into account that colecalciferol and its metabolites penetrate into the breast milk, so the intake of calcium and vitamin D3 must be considered.