Budesonide isiciler, for inhalation 200 mcg/dose 200 doses

Budesonide Isicheiler is a GKS for inhalation, intranasal and topical use. It has anti-inflammatory, anti-allergic and anti-exudative effect, which when administered by inhalation leads to a reduction of bronchial obstruction.

The mechanism of action consists in inhibition of release of mediators of inflammation and allergy, and reduction of respiratory tract reactivity to their action. During treatment, respiratory function improves, the severity and frequency of dyspnea, attacks of choking, coughing significantly decrease. The maximal clinical effect develops after 1-2 weeks of therapy.

Pharmacokinetics

Inhalation administration penetrates 30-35% of the dose into the bronchioles. The bioavailability upon entry into the lungs is about 73%. 25-30% enter the gastrointestinal tract. Bioavailability by oral route of administration is 10.7%.

The C_max of budesonide in plasma is reached after 1.5-2 hours.

Budesonide is rapidly excreted from the body. T_1/2 when administered by inhalation is 2-3 hours. Plasma clearance is 55-85 l/h.

Indications

Bronchial asthma requiring maintenance therapy with glucocorticoids.

Active ingredient

How to take, the dosage

In case of inhalation use, the dose is set depending on the indication, age, and method of inhalation.

Interaction

Cimetidine and omeprazole have no clinically significant effect on the pharmacokinetic parameters of budesonide when administered orally. However, under the influence of cimetidine, metabolism of budesonide in the liver may be delayed.

Special Instructions

With caution is used in patients with pulmonary tuberculosis, as well as in case of chicken pox.
Budesonide is not intended to relieve acute attacks of suffocation in bronchial asthma. It is not recommended for use in the intermittent course of the disease.

The change from systemic GCS to inhalation is gradual.

The efficacy and safety of budesonide in children under 7 years of age has not been studied.

Impact on ability to drive and operate machinery

Budesonide does not affect the ability to engage in potentially dangerous activities requiring increased attention and high speed of psychomotor reactions.

Contraindications

Hypersensitivity to budesonide.

Side effects

Respiratory system: with inhalation use irritation of the mucous membranes of the pharynx, oral cavity, nose, candidiasis are possible; with hypersensitivity – bronchospasm.

Pregnancy use

Pregnant use is possible when the estimated benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to use during lactation, breastfeeding should be stopped due to the lack of data on excretion of budesonide with the breast milk.

Similarities