Bronchobos, 125 mg/5 ml syrup 200 ml

Pharmacotherapeutic group
Mucolytic expectorant.

TAC code
R05SB03

Pharmacological properties

Pharmacodynamics
Mucolytic and expectorant action is caused by activation of sialic transferase – enzyme of the mucous membrane of the bronchi. Normalizes
the quantitative ratio of acidic and neutral sialomucin bronchial secretion, restores the viscosity and elasticity of mucus. Contributes to the regeneration
of the mucous membrane, normalizes its structure, activates the ciliated epithelium. Restores the secretion of immunologically active IgA (specific protection) and the number of sulfhydryl groups of mucus components (nonspecific protection), improves mucociliary clearance.

Pharmacokinetics
Absorption is fast and almost complete. Bioavailability is low (less than 10% of the dose taken). Time of maximum concentration achievement in blood and mucous membranes is 1.5-2 hours; therapeutic concentration is retained in blood during 8 hours. It is retained for the longest time in the blood, liver and middle ear. It is accumulated in high concentrations in bronchial secretion (17.5% of the administered dose).
Metabolized in the liver (has the effect of “first passage” through the liver). Excreted by the kidneys (60-90% unchanged, the rest – as metabolites). The elimination half-life is 2-3.15 hours. Complete excretion occurs after 3 days.

Indications

Active ingredient

Composition

Active ingredients:
5 ml of 2.5% syrup (1 scoop) contains: carbocysteine 125.00 mg.
5 ml of 5% syrup (1 scoop) contains: carbocysteine 250.00 mg.
Excipients: glycerol 135.00 mg, ethanol 96% 125.00 mg, sodium hydroxide 30.5 mg (61.00 mg), sodium carmellose 20.00 mg, citric acid monohydrate 5.00 mg (10.00 mg), methyl parahydroxybenzoate 9.00 mg, sodium saccharinate 5.00 mg, propyl parahydroxybenzoate 1.00 mg, raspberry flavoring 0.70 mg, azorubin CI 14720 (E 122) 0.05 mg, purified water to 5.00 ml.

How to take, the dosage

For dosage of the syrup use a scoop of 5 ml, graduated in 2.5 ml.
1 measuring spoon of 5% syrup (5 ml) = 250 mg carbocysteine
1 measuring spoon of 2.5% syrup (5 ml) = 125 mg carbocysteine
Adults: 15 ml (3 measuring spoons) of 5% syrup three times a day.
Children of 3-6 years old – 5 ml (1 measuring spoon) of 2.5% syrup 2-4 times a day.
Children over 6 years old – 5-10 ml (1 -2 measuring spoons) of 2.5% syrup 3 times a day.

Interaction

Increases the effectiveness of glucocorticoid (mutually) and antibacterial therapy of infectious and inflammatory diseases of the upper and lower respiratory tract.
Potentiates the bronchodilator effect of theophylline. Carbocysteine activity is weakened by anti-cough and atropine-like drugs.
Due to the content of alcohol, Bronchobos is prescribed with caution with the following drugs:
Drugs that cause adverse reactions (fever, redness, vomiting, tachycardia) when taken simultaneously with alcoholic beverages: disulfiram, cefamandole,
cefoperazone, latamoxef (cephalosporin antibiotics), chloramphenicol (phenicol antibiotic), chlorpropamide, glibenclamide, glipizide, tolbutamide (sulfamide antidiabetic drugs), griseofulvin (antifungal drug), nitro-5-imidazoles (metronidazole, ornidazole, secnidazole, tinidazole), ketoconazole, procarbazine (cytostatic).
Drugs that depress the central nervous system.

Special Instructions

The alcohol content of the drug is 125 mg/5 ml, i.e. 125 mg of alcohol per scoop.

Impact on the ability to drive vehicles and work on machines.
Impairment of psychomotor reactions associated with the presence of alcohol in the drug can be dangerous when driving a car or working on machines.

Synopsis

Contraindications

– Liver diseases;
– Alcoholism;
– Epilepsy;
– Trauma or brain disease;
– Hypersensitivity to the drug or its auxiliary components;
– Peptic ulcer in the acute stage;
– Chronic glomerulonephritis (in the acute stage);
– Cystitis;
– Childhood under 3 years old (for 2.5% syrup), children under 15 years old (for 5% syrup).

With caution
Peptic ulcer and 12 duodenal ulcer (in anamnesis).

Side effects

Gastrointestinal tract:
Sometimes nausea, vomiting, diarrhea and pain in the epigastrium, gastrointestinal bleeding.

Hypersensitivity reactions:
Single cases of allergic reactions (skin itching, urticaria, exanthema, angioedema) were noted.

Others: dizziness, weakness, malaise.
In patients with bronchial asthma and elderly patients, airway obstruction may occur.

Overdose

Pregnancy use

The use in pregnancy and lactation is contraindicated.

Similarities