Braunodin B. Brown, 10% ointment 20 g

The antiseptic agent is a complex of iodine and povidone, effective at pH from 2 to 7.

The bactericidal effect is due to free active iodine that is released from the povidone-iodine complex.

In comparison with alcohol-containing iodine solutions, aqueous solution of povidone-iodine has significantly less irritating effect.

Free iodine as a strong oxidizing agent reacts on molecular level with insoluble fatty acids and rarely oxidized SH- and OH-groups of amino acids within enzymes and main structural components of Gram-positive and Gram-negative bacteria, mycobacteria, fungi, especially Candida type, various viruses and some protozoa.

However, the complete inactivation of some viruses and bacterial spores requires a fairly long period of exposure to the drug. There are no known cases of the development of resistance in microorganisms with prolonged use of povidone iodine.

Indications

Post-traumatic and postoperative wounds of different localization, burns, trophic ulcers, bedsores.

Infections of different skin aetiology including infectious dermatitis and eczema.

Damage to the skin of various origins (maceration, abrasions, contusions).

Active ingredient

Composition

The active ingredient:

povidone iodine (with 10% active iodine content) 10.0 g.

How to take, the dosage

Externally. The drug is applied to the affected surface one to several times a day until the symptoms of inflammation disappear.

If necessary, bandages, gauze swabs and turundas are used. The frequency and duration of application of the ointment depends on the course of the wound process.

The course of treatment is 5-10 days.

Interaction

The drug is incompatible with alkaloid salts (celandine), tannic acid (tannin), salicylic acid, salts of silver, bismuth, taurolidine and hydrogen peroxide. In the presence of blood and pus the drug binds to proteins and other organic compounds, as a result of which its bactericidal activity may be reduced.

In this case it is recommended to increase the multiplicity/frequency of its use. If povidone iodine and enzyme preparations are used at the same time, it may cause oxidation and inhibition of enzymatic activity.

Povidone iodine synergizes with lithium preparations and reversible suppression of thyroid function is possible with prolonged use. Therefore, patients who regularly take lithium preparations should avoid long-term application of povidone iodine on large surfaces.

The drug may lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool, examination of thyroid function, etc. Thyroid examination in this case should not be performed earlier than 1-2 weeks after the end of treatment with povidone iodine.

Contraindications

Hypersensitivity to the components of the drug. Thyroid disorders (thyrotoxicosis). Adenoma of the thyroid gland. Duhring’s dermatitis herpetiformis.

Concomitant use of radioactive iodine. Premature infants, newborns and children under 6 months of age.

Side effects

Hypersensitivity reactions to the drug are possible: delayed type allergic reactions (itching, redness of the skin, blisters) or immediate type allergic reactions (anaphylactoid reactions).

. Long use of the drug (more than 7-10 days) and application on large skin surfaces, large wounds due to absorption may lead to iodine phenomena (“metallic” taste in the mouth, increased salivation and lacrimation, edema of mucous membranes) and system reactions (metabolic acidosis, hyponatremia, renal and thyroid disorders), if they occur, the drug use should be stopped and a doctor should be consulted.

Overdose

In intensive absorption of iodine for a long period, the following symptoms may be noted: tachycardia, agitation, tremor and headache.

In this case, the drug should be stopped immediately and a doctor should be consulted.

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