Braunodin B. Brown, 10% ointment 100 g

Povidone iodine is an antiseptic agent that is a complex of iodine and povidone effective at pH 2 to 7.

The bactericidal effect is due to free active iodine, which in the ointment is released from the povidone-iodine complex. As a strong oxidizing agent, free iodine reacts on the molecular level with insoluble fatty acids and almost non-oxidizing SH- and OH-groups of amino acids, which are part of enzymes and main structural components of bacteria, both Gram-positive and Gram-negative mycobacteria, fungi, especially Candida, various viruses and some protozoa. However, for the complete inactivation of some viruses and bacterial spores a fairly long period of exposure to the drug is required.

There are no known cases of development of resistance in microorganisms after long-term use of povidone iodine.

Pharmacokinetics:

Indications

Post-traumatic and postoperative wounds of different localization, burns, trophic ulcers, bedsores.

Dermal infections of various etiologies, including infectious dermatitis and eczema.

Injuries to the skin of different origin (maceration, abrasions, contusions).

Active ingredient

Composition

Interaction

The drug is incompatible with alkaloid salts (celandine), tannic acid (tannin), salicylic acid, salts of silver, bismuth, taurolidine and hydrogen peroxide.

In the presence of blood and pus the drug binds to proteins and other organic compounds, as a result of which its bactericidal activity may be reduced. In this case it is recommended to increase the multiplicity/frequency of its use.

The simultaneous use of povidone iodine and topical products containing enzymes may contribute to oxidation and inhibition of their enzymatic activity.

Povidone iodine has a synergistic effect with lithium preparations, and therefore reversible suppression of thyroid function may occur with prolonged use. Therefore, patients who routinely take lithium preparations should avoid prolonged application of povidone iodine to large surfaces.

The drug may lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool, thyroid function tests, etc. Thyroid examination in this case should not be performed earlier than 1-2 weeks after the end of treatment with povidone iodine.

Special Instructions

Avoid getting the drug in the eyes.

The drug may lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool thyroid function tests, etc. Thyroid examination in this case should not be performed earlier than 1-2 weeks after the end of treatment with povidone iodine.

The bactericidal effect of povidone iodine may be reduced in the presence of blood.

In case of thyroid dysfunction, the use of the drug is possible only under medical supervision. Administration in infants is possible only if necessary after investigation of thyroid function.

Cautions should be taken with regular use in patients with chronic renal insufficiency.

The drug may stain skin and clothing when used; it can be easily washed off and removed with water.

To read these instructions carefully before you start taking this medicine, because they contain important information for you.

The drug does not affect your ability to drive or engage in other potentially dangerous activities that require increased concentration and quick psychomotor reaction.

Synopsis

Contraindications

Hypersensitivity to the components of the drug.

Disorders of thyroid function (thyrotoxicosis).

Adenoma of the thyroid gland.

During dermatitis herpetiformis.

Concomitant use of radioactive iodine.

Premature infants, newborns and children under 6 months.

With caution

Chronic renal failure.

Side effects

Hypersensitivity reactions to the drug are possible: delayed-type allergic reactions (itching, redness of the skin, blisters) or immediate-type allergic reactions (anaphylactoid reactions).

. Long use of the drug (more than 7-10 days) and application to large skin surfaces, large wounds due to absorption may lead to iodine phenomena (“metallic” taste in the mouth, increased salivation and lacrimation, mucous membrane edema) and system reactions (metabolic acidosis, hyponatremia, renal and thyroid disorders), if they occur, the drug use should be stopped and a doctor should be consulted.

Overdose

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