Biltricide, 600 mg 6 pcs.

BILTRICIDE is an anthelmintic drug. It increases permeability of helminth cell membranes for calcium ions, which causes generalized contraction of parasite muscles, and also inhibits glucose capture by helminth cells, thus glycogen level decreases and release of lactic acid compounds is stimulated. As a result, death of parasites occurs. Praziquantel is specifically active against trematodes and cestodes.

Pharmacokinetics

Intake

After oral administration praziquantel is quickly and completely absorbed. The maximum plasma concentration is reached within 1-2 hours. Period of half-life of the drug in unchanged form is 1-2.5 hours, together with metabolites – 4 hours.

To achieve therapeutic effect the plasma concentration of the drug must be maintained for 4-6 (maximum up to 10) hours to 0.19 mg/l.

Distribution

The drug penetrates through the barrier. Concentration in cerebrospinal fluid is 10-20% of its concentration in blood plasma. It penetrates into breast milk at a concentration of 20-25% of its concentration in blood serum.

Metabolism

It is subjected to metabolism during “first passage” through the liver. The main metabolites are hydroxylated degradation products of praziquantel.

Elimination

Extracted mainly by the kidneys. More than 80% of the dose is excreted within 4 days, with 90% of this amount excreted within 24 hours.

Pharmacokinetics in special clinical cases

Because the drug has a predominantly renal route of excretion, there may be delayed excretion in renal insufficiency.

In decompensated hepatic insufficiency the drug metabolism in the liver is decreased, which is accompanied by prolongation of T1/2 and increased concentration of praziquantel in blood.

Indications

– Treatment of infections caused by different species of schistosomes (S. haematobium, S. mansoni, S.intercalatum, S.japonicum, S.Treatment of infections caused by liver fluke (Clonorchis sinensis, Opistorchis viverrini) and lung fluke (Paragonimus westermani, other species).

Active ingredient

Composition

1 tablet contains:

Active substances:

praziquantel 600 mg.

Associates:

Corn starch,

microcrystalline cellulose,

polyvinylpyrrolidone,

sodium lauryl sulfate,

magnesium stearate,

hypromellose,

polyethylene glycol MG 4000,

titanium dioxide.

How to take, the dosage

To the mouth, whole, without chewing, with a small amount of liquid, before or with a meal. If a single use of the drug per day is recommended, the tablet should be taken in the evening. When using the drug multiple times during the day, an interval between doses of at least 4 and no more than 6 hours is recommended.

Adults and children over 4 years of age. Doses of Biltricid® are chosen strictly individually and depend on the type of pathogen.

Schistosoma haematobium – 40 mg/kg body weight once. The duration of treatment is 1 day.

Schistosoma mansoni and Schistosoma intercalatum – 40 mg/kg once daily or 20 mg/kg 2 times daily. The duration of treatment is 1 day.

Schistosoma japonicum, Schistosoma mekongi – 60 mg/kg once daily or 30 mg/kg 2 times daily. Duration of treatment – 1 day.

Clonorchis sinensis, Opisthorchis viverrini – 25 mg/kg 3 times a day for 1-3 days.

Paragonimus westermani and other species – 25 mg/kg 3 times per day for 2-3 days.

Children under 4 years of age. The safety of the drug in children younger than 4 years has not been established.

Interaction

In concomitant use with drugs inducing liver enzymes of the cytochrome P450 system, e.g. anticonvulsants, dexamethasone, the plasma concentration of praziquantel may decrease, and in combination with drugs that inhibit these enzymes, such as cimetidine – increase.

Chloroquin decreases the plasma concentration of praziquantel.

Special Instructions

Simultaneous administration of laxatives is not required.

When treating patients with uncomplicated liver failure or with hepatosplenic schistosomiasis with Biltricid, higher concentrations and prolonged T1/2 (slowed metabolism) are noted, and treatment should be performed under hospital conditions.

Contraindications

– Hypersensitivity to any component of the drug Biltricid;
– Cysticercosis eyes;
– Combined use with rifampicin.
– Children under 4 years of age (safety and effectiveness is not established)
With caution. Decompensated liver failure, hepatolien schistosomiasis, heart rhythm disorders.

Side effects

Digestive system disorders: abdominal pain, nausea, vomiting; lack of appetite; diarrhea with blood admixture.

CNS disorders: headache, dizziness; dizziness, drowsiness; seizures.

Activities of the body in general: asthenia, fever.

Muscular system disorders: myalgia.

Cardiovascular system: arrhythmia.

Allergic reactions: urticaria; generalized allergic reactions, including polyserositis.