Bicana, 50 mg 28 pcs.

Bicalutamide is an antitumor agent; it is a racemic mixture with nonsteroidal antiandrogenic activity of predominantly (R)-enantiomer; it has no other endocrine activity.

Bicalutamide binds to androgen receptors on the surface of target organ cells, suppressing the stimulating effects of androgens without activating gene expression. As a result there is regression of prostate malignancies.

In some patients discontinuation of bicalutamide may lead to development of clinical syndrome “withdrawal” of antiandrogens.

Indications

Prostate cancer:

– treatment of advanced prostate cancer in combination with a gonadotropin-releasing hormone analogue (GnRH analogue) or surgical castration;

– monotherapy or adjuvant therapy in combination with radical prostatectomy or radiotherapy for locally advanced prostate cancer (T3-T4, any N, M0; T1-T2, N+, M0);

– treatment of locally advanced, non-metastatic prostate cancer in cases where surgical castration or other medical interventions are unacceptable or not applicable.

Pharmacological effect

Bicalutamide is an antitumor agent, it is a racemic mixture with non-steroidal antiandrogenic activity, predominantly of the (R)-enantiomer, and has no other endocrine activity.

Bicalutamide binds to androgen receptors on the surface of cells in target organs, suppresses the stimulating effects of androgens without activating gene expression. As a result, regression of malignant neoplasms of the prostate gland occurs.

In some patients, discontinuation of bicalutamide may lead to the development of clinical antiandrogen withdrawal syndrome.

Active ingredient

Bicalutamide

Composition

1 tablet contains:

Active substance:

bicalutamide 50 mg;

Excipients:

Magnesium aluminum metasilicate,

Sodium carboxymethyl starch,

Magnesium stearate,

Ludipress (lactose monohydrate, lovidone, crospovidone).

Contraindications

Hypersensitivity to bicalutamide or any other component of Bicana.

Concomitant use of terfenadine, astemizole and cisapride.

Bicalutamide is contraindicated in children and women.

With caution:

Lactose intolerance, lactase deficiency and glucose-galactose malabsorption (since the drug contains lactose); liver dysfunction; simultaneous use with cyclosporine or blockers of “slow” calcium channels; simultaneous use with drugs that inhibit microsomal oxidation of drugs (cimetidine or ketoconazole).

Manufacturer

Nativa, Russia