Bicana, 50 mg 28 pcs.

Bicalutamide is an antitumor agent; it is a racemic mixture with nonsteroidal antiandrogenic activity of predominantly (R)-enantiomer; it has no other endocrine activity.

Bicalutamide binds to androgen receptors on the surface of target organ cells, suppressing the stimulating effects of androgens without activating gene expression. As a result there is regression of prostate malignancies.

In some patients discontinuation of bicalutamide may lead to development of clinical syndrome “withdrawal” of antiandrogens.

Indications

Prostate cancer:

– treatment of advanced prostate cancer in combination with a gonadotropin-releasing hormone analog (GnRH analog) or surgical castration;

– monotherapy or adjuvant therapy in combination with radical prostatectomy or radiotherapy for locally advanced prostate cancer (T3-T4, any N, M0; T1-T2, N+, M0);

– treatment of locally advanced, non-metastatic prostate cancer when surgical castration or other medical interventions are unacceptable or not applicable.

Active ingredient

Composition

1 tablet contains:

Active substance:

bicalutamide 50 mg;

Associates:

Magnesium aluminosilicate,

Sodium carboxymethyl starch,

How to take, the dosage

Ingestion, regardless of meals, with plenty of fluids.

Bicana is indicated for adult men (including elderly men).
In advanced prostate cancer – orally, 50 mg once daily, in combination with simultaneous initiation of GnRH analogue treatment or surgical castration.

In locally advanced non-metastatic prostate cancer, 150 mg once daily.

Bicalutamide should be taken long-term, for at least 2 years.

If there are signs of disease progression, the drug should be stopped.

Renal dysfunction: No dose adjustment is required.

Hepatic impairment: patients with mild hepatic impairment do not require dose adjustment.

In patients with moderate to severe hepatic impairment, increased cumulation of bicalutamide is possible; therefore, Bicana should be used with caution.

Contraindications

Hypersensitivity to bicalutamide or any other component of Bicana.

Simultaneous use of terfenadine, astemizole and cisapride.

Bicalutamide is contraindicated in children and women.

With caution:

Lactose intolerance, lactase deficiency and glucose-galactose malabsorption (t.к.

Lactose intolerance; liver function abnormality; simultaneous use with cyclosporine or “slow” calcium channel blockers; simultaneous use with agents that inhibit microsomal oxidation of drugs (cimetidine or ketoconazole).

Similarities