Bicalutamide Canon, 150 mg 30 pcs

Cancer

Prostate cancer – as part of combination therapy with a GnRH analogue or with surgical castration.

Active ingredient

Composition

The active ingredients:

Bicalutamide 150 mg.

Excipients:

corn starch 107 mg,

croscarmellose sodium 19.5 mg,

p> lactose monohydrate 132.9 mg,

povidone 7.6 mg,

sodium stearyl fumarate 3 mg.

The composition of the film coating:

Opadray II white 12 mg.

How to take, the dosage

Individual, depending on the indication and treatment regimen.

Interaction

When bicalutamide was used for 28 days against midazolam, the AUC of midazolam was increased by 80%.

Concomitant use of bicalutamide with cyclosporine or calcium channel blockers may result in potentiation or adverse reactions.

Theoretically it is possible to increase plasma concentrations of bicalutamide when used concomitantly with liver microsomal enzyme inhibitors, which may be accompanied by an increased incidence of adverse reactions.

In vitro studies have shown that bicalutamide can displace the coumarin-type anticoagulant warfarin from plasma protein binding sites.

Special Instructions

Use with caution in patients with moderate to severe hepatic dysfunction because bicalutamide may cumulate in the body.

Hepatic function should be monitored regularly during treatment. In case of development of severe changes it is necessary to discontinue bicalutamide.

Contraindications

Side effects

Endocrine system disorders: hot flashes, breast pain and gynecomastia, decreased libido.

Digestive system disorders: abdominal pain, diarrhea, nausea, vomiting, increased transaminase levels, jaundice, cholestasis.

CNS disorders: asthenia and depression are possible.

Dermatological reactions: alopecia, hair growth restoration, itching, dry skin.

Others: hematuria.

Overdose

There have been no cases of overdose in humans.

There is no specific antidote. Treatment is symptomatic.

Having dialysis is not effective because bicalutamide is firmly bound to proteins and is not excreted unchanged by the kidneys. General supportive therapy and monitoring of vital body functions are indicated.

Pregnancy use

It is not prescribed for female patients.

Similarities