Beclomethasone-Aeronativ, aerosol 50 µg/dose 200 doses

GCS for inhaled use. Beclomethasone in dipropionate form is a prodrug and has poor tropicity to glucocorticoid receptors.

Esterase converts it into the active metabolite, beclomethasone-17-monopropionate, which has a pronounced local anti-inflammatory effect by reducing the formation of chemotaxis substance (effect on delayed-type allergic reactions).

Inhibiting production of arachidonic acid metabolites and reducing release of inflammatory mediators from mast cells, inhibits development of immediate-type allergic reactions.

It improves mucociliary transport, decreases the number of mast cells in the bronchial mucosa, reduces epithelial edema, mucus secretion by bronchial glands, bronchial hyperresponsiveness, margin accumulation of neutrophils, inflammatory exudate and lymphokine production, inhibits macrophage migration, reduces the intensity of infiltration and granulation.

After inhalation administration it has practically no resorptive effect. It does not stop bronchospasm. The therapeutic effect develops gradually, usually after 5-7 days of course use.

Enhances the number of active β-adrenoreceptors, neutralizes their desensitization, restores the patient’s response to bronchodilators, allowing a reduction in the frequency of their use.

Indications

Active ingredient

Composition

Active ingredient:

0.555 mg beclomethasone dipropionate.

Excipients:

polysorbate 80,

dextrose,

microcrystalline cellulose,

benzalkonium chloride,

/p>

sodium hydroxide solution (1M) or hydrochloric acid solution (1M),

purified water.

How to take, the dosage

Beclomethasone is used regularly (even in the absence of symptoms of the disease).

The dose and regimen of treatment depend on age, the severity of the course of bronchial asthma, and the clinical effect in each case.

Special inhalation devices may be used for inhalation administration of beclamentazone dipropionate (according to the dosage form used).

Adults and children aged 12 years and older: The daily dose is 200-2000 mcg.

Children aged 4 to 12 years: the daily dose is 100-400 mcg.

Interaction

Beta-adrenomimetics – Beclomethasone enhances the effect of beta-adrenomimetics. Beclomethasone restores the patient’s response to beta-adrenomimetics, allowing a reduction in the frequency of their use.

Microsomal oxidation inducers (including phenobarbital, phenytoin, rifampicin) may decrease the effectiveness of beclomethasone.

Methandienone, estrogens, beta2-adrenomimetics, theophylline, systemic GCS – increase the effects of beclomethasone.

Special Instructions

Beclomethasone is not intended to relieve acute asthma attacks. It should also not be used in severe attacks of bronchial asthma requiring intensive therapy. The recommended route of administration for the dosage form used should be strictly observed.

Beclomethasone should be used with extreme caution and under close medical supervision in patients with adrenal insufficiency.

Transfer patients who are always on oral GCS to inhaled forms should only be done when they are stable.

If paradoxical bronchospasm is likely to develop, bronchodilators (e.g., salbutamol) should be inhaled 10-15 minutes before inhaling beclomethasone.

If candidiasis of the oral cavity and upper respiratory tract develops, local antifungal therapy is indicated without stopping treatment with beclomethasone. Infectious inflammatory diseases of the nasal cavity and sinuses are not contraindications to beclomethasone therapy when therapy is indicated.

Inhaled preparations containing 250 mcg beclometasone in 1 dose are not indicated for children under 12 years of age.

Contraindications

Tuberculosis (active and inactive); childhood under 4 years; childhood and adolescence under 18 years (for dosage forms containing 250 mcg beclometasone in 1 dose); hypersensitivity to beclometasone.

Glaucoma; systemic infections (bacterial, viral, fungal, parasitic); osteoporosis; cirrhosis of the liver; hypothyroidism; pregnancy; period of lactation (breastfeeding).

Side effects

Overdose

Pregnancy use

Similarities