Basiron AS, gel 2.5% 40 g

Baziron AC has high antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, has a comedolytic and anti-inflammatory effect, improves tissue oxygenation, suppresses sebum production in sebaceous glands, absorbs excess sebum and moisturizes the skin.

In in vivo studies on culture results, it has been shown to suppress Propionibacterium acnes culture growth by 94% by day 7 and 97-99% by day 15.

The anti-inflammatory effect of benzoyl peroxide is based on the inactivation of free radicals in the focus of inflammation and inhibition of free fatty acids.

The base of the product is an acrylate copolymer/glycerol complex to ensure controlled adsorption of excess sebum and the gradual release of glycerol to soften and moisturize the skin.

Pharmacokinetics

The penetration of benzoyl peroxide through the skin is low. Most of the benzoyl peroxide is converted to benzoic acid, which after absorption enters the systemic bloodstream and is rapidly excreted by the kidneys.

There is no cumulation in the tissues. Topical application of Basiron AS in therapeutic doses does not lead to adverse systemic effects.

Indications

Acne.

Active ingredient

Composition

1 g of gel for external use contains:

active ingredient:

benzoyl peroxide 25 mg;

supplements:

amethacrylic acid copolymer;

poloxamer 182;

carbomer 940;

glycerol;

dinatrium edetate;

How to take, the dosage

The gel should be applied to a clean and dry surface of the affected skin once or twice a day (morning or evening).

The course of treatment is 3 months. Therapeutic effect occurs 4 weeks after the start of treatment. Stable improvement occurs after 3 months of therapy.

Basirone AC is indicated for the treatment of mild to moderate acne with predominance of pustular elements as monotherapy, and in moderate acne also in combination with other topical (retinoids) and systemic (antibiotics, oral antiandrogens).

A second course of treatment is possible if necessary.

Special Instructions

Avoid contact of Basiron AC gel with the mucous membranes of the eyes, mouth and nose.

In case of accidental contact of the drug with the mucous membranes, rinse them thoroughly with warm water.

The simultaneous use of products with exfoliating, drying or irritating properties (e.g., products containing alcohol) is not recommended.

Prevent sun exposure and UV exposure, which are additional causes of skin irritation.

Contraindications

Hypersensitivity to one of the ingredients of the drug; children under 12 years of age.

Side effects

In rare cases: local irritation – redness, peeling, dry skin, burning sensation (it is recommended to reduce the frequency of use); allergic contact dermatitis.

Pregnancy use

Controlled clinical trials of the drug in pregnancy and lactation have not been conducted.

In the long period of clinical use of Basiron AS no cases of toxic effect on the fetus or malformations have been noted.

The use of Basiron AS gel in pregnancy and breastfeeding is possible when the expected benefits to the mother exceed the potential risk to the fetus.