Baralgin M, tablets 500 mg 100 pcs

Baralgin is antispasmodic, analgesic, antipyretic, anti-inflammatory.

Blocks cyclooxygenase and reduces GH synthesis.

Pharmacokinetics

. After oral administration, it is hydrolyzed in the gastrointestinal tract to form the active metabolite, 4-methylaminoantipyrine (4-MMA), which is absorbed in the liver to 4-aminoantipyrine (4-AA), as well as pharmacologically inactive metabolites.

After ingestion of 1 g of metamizole, 58% of 4-MMA and 48% of 4-AA are bound to plasma proteins.

The effective therapeutic plasma concentration of 4-MMA is reached after 20-40 min, Cmax after 2 h.

Indications

Active ingredient

Composition

Active ingredient:

Metamizole sodium 500 mg;

Supplements:

Macrogol 4000 47 mg,

Magnesium stearate 3 mg.

How to take, the dosage

In tablets, 1-2 tablets are prescribed for adults. Baralgin up to 4 times a day.

The maximum daily dose is not more than 8 tablets.

Interaction

Simultaneous use of metamizole with other non-narcotic analgesics may lead to a mutual increase in toxic effects.

Tricyclic antidepressants, oral contraceptives, allopurinol impair metabolism of metamizole in the liver and increase its toxicity.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effects of metamizole. Sedatives and tranquilizers increase the analgesic effect of the drug. Concomitant use with chlorpromazine or other phenothiazine derivatives may lead to marked hyperthermia.

Rentgen contrast agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.

Methamisole displaces oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroid agents and indomethacin from binding to protein and increases their activity.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Special Instructions

In patients suffering from bronchial asthma, taking the drug can provoke a seizure.

Contraindications

– Disorders of medullary hematopoiesis (e.g., after treatment with cytostatics) or diseases of the hematopoietic system.

– A history of bronchospasm or other anaphylactic reactions (e.g., urticaria, rhinitis, angioedema) when taking analgesic drugs such as salicylates, paracetamol, diclofenac, ibuprofen, indomethacin, naproxen.

– Congenital deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis).

– Childhood (under 15 years).

– Pregnancy (first and third trimester).

– Period of lactation.

– Acute intermittent hepatic porphyria (risk of porphyria attacks).

If you have any of these diseases or conditions, consult your doctor before taking this medicine.

– Hypotension (systolic blood pressure below 100 mm Hg.), decreased circulating blood volume, hemodynamic instability (myocardial infarction, multiple trauma, incipient shock), incipient heart failure, high fever (increased risk of rapid decrease in blood pressure).

– Diseases in which a significant decrease in blood pressure may have an increased risk (patients with severe coronary heart disease and cerebral artery stenosis).

– Alcoholism.

– Bronchial asthma, especially in combination with concomitant polyposis rhinosinusitis; chronic urticaria and other types of atopy (allergic diseases in the development of which a significant role belongs to genetic predisposition to sensitization: pollinosis, allergic rhinitis, etc.) (increased risk of anaphylactic/anaphylactoid reactions).

– Alcohol intolerance (reaction to even small amounts of certain alcoholic beverages with symptoms such as itching, lacrimation, and pronounced redness of the face) (increased risk of anaphylactic/anaphylactoid reactions).

– Intolerance to dyes (e.g., tartrazine) or preservatives (e.g., benzoates) (increased risk of anaphylactic/anaphylactoid reactions).

– Severe hepatic and renal dysfunction (low doses are recommended due to the possibility of delayed excretion of sodium metamizole).

– Pregnancy (second trimester).

Side effects

Overdose

Symptoms

The following symptoms may occur in overdose: Nausea, vomiting, abdominal pain, decreased renal function/acute renal failure with oliguria (e.g., due to the development of interstitial nephritis), more rarely symptoms of the central nervous system (dizziness, drowsiness, tinnitus, delirium, impaired consciousness, coma, seizures) and a sharp decrease in blood pressure (sometimes progressing to shock), as well as cardiac rhythm disorders (tachycardia), hypothermia, shortness of breath, acute agranulocytosis, hemorrhagic syndrome, acute liver failure, respiratory muscle paralysis. After high doses, excretion through the kidneys of the non-toxic metabolite (rubazonic acid) may cause red staining of the urine.

Treatment

If no more than 1-2 hours have passed after taking the drug, it is possible to induce vomiting, gastric lavage through a tube; give saline laxatives, activated charcoal. In case of overdose, forced diuresis is indicated. The main metabolite (4-N-methylaminoantipyrine) may be excreted by hemodialysis, hemofiltration, hemoperfusion or plasma filtration. If seizure syndrome develops, intravenous administration of diazepam and fast-acting barbiturates.

Pregnancy use

Similarities