Baneocin, ointment 250 me/g+5000 me/g 20 g

Pharmacodynamics

Baneocin is a combined antibacterial drug for topical use.

Baneocin contains two bactericidal antibiotics: neomycin and bacitracin.

Bacitracin is a polypeptide antibiotic that inhibits the synthesis of the bacterial cell membrane.

Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis.

Bacitracin is active against Gram-positive microorganisms such as beta-haemolytic streptococci, staphylococci, and some Gram-negative pathogens. Resistance to bacitracin is extremely rare.

Neomycin is effective against Gram-positive and Gram-negative microorganisms.

The combination of the two agents has achieved a broad spectrum of the drug and synergistic action against a number of microorganisms, such as Staphylococcus aureus.

Pharmacokinetics

The active ingredients are generally not absorbed (even by damaged skin), but high concentrations are present in the skin.

Baneocin is well tolerated. Tissue tolerance is rated as excellent, no inactivation by biological products, blood and tissue components has been noted. If the drug is applied to large areas of skin lesions, the possibility of absorption of the drug and its consequences must be taken into account.

Indications

Baneocin is indicated for use in infections caused by microorganisms sensitive to neomycin and/or bacitracin.

Active ingredient

Composition

1 g of the ointment contains:

Active ingredients: bacitracin (in the form of bacitracin zinc) – 250 IU; neomycin (in the form of neomycin sulfate) – 5000 IU.

Excipients: lanolin, soft white paraffin.

How to take, the dosage

Apply the necessary amount of ointment to the treatment site, if appropriate, under a bandage.

In adults and children, Baneocin ointment is usually used two to three times a day.

When used topically, the dose of neomycin should not exceed 1 g per day (corresponding to 200 g of powder or ointment) for 7 days.

In a repeated course, the maximum dose should be reduced by half.

Interaction

If systemic absorption occurs, concomitant use of cephalosporins or aminoglycoside antibiotics may increase the likelihood of a nephrotoxic reaction.

The concomitant use of diuretics such as etacrynic acid or furosemide with Baneocin may provoke ototoxic and nephrotoxic effects.

The absorption of Baneocin may potentiate the phenomena of neuromuscular conduction blockade in patients receiving narcotics, anesthetics and muscle relaxants.

There have been no cases of incompatibility for bacitracin and neomycin.

Special Instructions

When used in doses significantly higher than recommended, due to possible absorption of Baneocin, special attention should be paid to symptoms indicating nephro- and/or ototoxic reactions.

Because the risk of toxic effects increases with decreased liver and/or renal function, blood and urine tests should be performed in patients with hepatic and/or renal impairment along with audiometric testing before and during therapy with Baneocin.

If absorption of Baneocin occurs, attention should be paid to potential blockade of neuromuscular conduction, especially in patients with acidosis, concomitant severe myasthenia gravis or other neuromuscular diseases.

In long-term treatment, attention should be paid to the possible growth of resistant microorganisms. Appropriate treatment should be prescribed in these situations.

In children, patients with compromised liver or kidney function, as well as patients with a large surface area to be treated, prolonged use and deep skin lesions, it is recommended that a physician be consulted in advance.

Patients who develop an allergy or superinfection should have the drug discontinued.

Contraindications

With caution:

Side effects

Baneocin is usually well tolerated when applied topically to the skin, mucous membranes and wound surfaces.

Patients who use the drug for a long time may develop allergic reactions in the form of red and dry skin, skin rashes and itching.

Allergic reactions are mostly of the contact eczema type and are rare. In about 50% of cases they are associated with cross-allergies to other aminoglycoside antibiotics.

When treating patients with extensive skin lesions, the possibility of absorption of the drug and, as a consequence, the occurrence of complications such as vestibular and cochlear lesions, nephrotoxic effect and blockade of neuromuscular conduction must be considered.

Overdose

Pregnancy use

The use of Baneocin during pregnancy and breastfeeding is possible only after consultation with a physician, if the expected benefits to the mother exceed the potential risk to the fetus and the baby.