AzitRus, 250 mg capsules 6 pcs

AzitRus is a broad-spectrum antibiotic of the macrolide group, azalid.

It acts bacteriostatically.

Binding to the 50S-subunit of the ribosome, it inhibits protein synthesis and inhibits bacterial growth and reproduction.

AzitRus in high concentrations has a bactericidal effect.

It acts on extra- and intracellular pathogens

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
– Upper respiratory tract and ENT-organ infections (including, sore throat, sinusitis, tonsillitis, pharyngitis, otitis media)
– Infections of the lower respiratory tract (including, tonsillitis, pharyngitis, otitis media).Infections of the upper respiratory tract and ENT organs (including sore throat, sinusitis, tonsillitis, pharyngitis, otitis media);
– Lower respiratory tract infections (including.
– lower respiratory tract infections (including bacterial and atypical pneumonia, bronchitis);
– skin and soft tissue infections (including rye, impetigo, secondary infected dermatosis);
– urinary tract infections (gonorrhea and nongonorrhea urethritis);
– genital system infections (including cervicitis);
– urinary infections.Infections of the genital system (including cervicitis);
– scarlet fever;
– Lyme disease (borreliosis) in the initial stage (erythema migrans);
– gastric and duodenal diseases associated with Helicobacter pylori (in combined therapy).

Active ingredient

Composition

1 capsule contains azithromycin (in the form of dihydrate) 250 mg

How to take, the dosage

Infections of the upper and lower respiratory tracts are prescribed by 500 mg daily during 3 days (course dose – 1.5 g).

Interaction

When used concomitantly, antacids (aluminum- and magnesium-containing), ethanol and food slow down and decrease the absorption of azithromycin.

When co-administration of azithromycin in therapeutic doses with warfarin no changes in prothrombin time were observed, but taking into account that in case of interaction of macrolides with warfarin there may be increased anticoagulant effect, close monitoring of prothrombin time is necessary when prescribing this combination in patients.

Concomitant use increases plasma concentrations of digoxin.

The toxic effects (vasospasm, dysesthesia) of ergotamine and dihydroergotamine are increased with concomitant use.

Concomitant use decreases clearance and enhances the pharmacological effects of triazolam.

Azithromycin inhibits microsomal oxidation in hepatocytes which leads to delayed excretion and increased plasma concentrations and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine as well as drugs In addition to these drugs subject to microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine, phenytoin, oral hypoglycemic agents, xanthine derivatives, including theophylline), plasma concentrations and toxicity of cycloserine and other drugs subject to microsomal oxidation.including theophylline).

Lincosamines decrease the effectiveness of azithromycin.

Tetracycline and chloramphenicol increase the effectiveness of azithromycin.

Special Instructions

In case of missed doses, the missed dose should be taken as soon as possible, and the next ones – with an interval of 24 hours.
A break of at least 2 hours between doses of AzitRus and antacid drugs should be observed.

After discontinuation of the drug hypersensitivity reactions may persist in some patients, in these cases administration of specific therapy under medical supervision is recommended.

Contraindications

Patients with cardiac arrhythmia (ventricular arrhythmias and prolongation of QT interval are possible), children with significant renal or hepatic impairment and in pregnancy are treated with caution.

Side effects

Digestive system: possible – diarrhea (5%), nausea (3%), abdominal pain (3%); 1% – flatulence, vomiting, melena, cholestatic jaundice, increased liver transaminases activity; in children – constipation, decreased appetite, gastritis, oral candidiasis, change of taste.
Cardiovascular system: palpitations, chest pain.
CNS disorders: dizziness, headache, sleepiness; in children – headache (when treating otitis media), hyperkinesia, anxiety, neurosis, sleep disorders.
Urinary system disorders: nephritis.
Genital system: vaginal candidiasis.
Allergic reactions: rash, urticaria, itching, angioedema; in children – conjunctivitis, itching, urticaria.

Overdose

Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: gastric lavage, symptomatic therapy.

Similarities