Azelik, gel 15% 5 g

Pharmacological group:

Acne rash treatment
ATX code D10AX03

Pharmacodynamics:

Aselaic acid in the therapy of acne normalizes the disturbed processes of keratinization in the follicles of sebaceous glands, and reduces the content of free fatty acids in the skin lipids. It shows antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. The mechanism of action of azelaic acid in rosacea is unknown.

It may be assumed that the anti-inflammatory effect is caused by a decrease in neutrophil metabolism and the production of free-radical oxygen species. Azelaic acid has a dose-dependent and time-dependent suppressive effect on the growth and activity of abnormal melanocytes.

Pharmacokinetics:

Azelaic acid penetrates into the epidermis and dermis after application to the skin, penetration into damaged skin is faster than in intact skin. After a single external application of 5 g gel, 3.6% of the total dose of azelaic acid enters the systemic bloodstream. Part of the absorbed acid is excreted by the kidneys unchanged, part of it – in the form of dicarboxylic acids (C7, C5), formed as a result of beta-oxidation.

Indications

Acne vulgaris, Rosacea.

Active ingredient

Composition

How to take, the dosage

Special Instructions

Contraindications

Hypersensitivity to the ingredients of the drug.

Side effects

In the beginning of treatment there may be local irritation, skin hyperemia and peeling, burning, erythema, itching, which usually disappear during treatment. Allergic skin reactions are possible.

Overdose

Pregnancy use

In pregnancy and during breastfeeding, use only if the estimated benefit to the mother outweighs the risk to the fetus and child.

Similarities