Azaran, 1 g, 10 pcs.

Azaran is a third-generation broad-spectrum cephalosporin antibiotic for parenteral administration.

Azaran acts bactericidally by inhibiting the synthesis of the cell membrane of microorganisms.

Acetylates membrane-bound transpeptidases, thus disrupting cross-linking of peptidoglycans necessary for the strength and rigidity of the cell wall.

Resistant against b-lactamases produced by most Gram-positive and Gram-negative bacteria.

It is active against Gram-positive aerobic bacteria. Methicillin-resistant strains are resistant to the drug.

Indications

Treatment of infections and inflammatory diseases caused by sensitive microorganisms:
– upper and lower respiratory tract infections (including.Upper and lower respiratory tract infections (including pneumonia, pulmonary abscess, pleural empyema);
– Skin and soft tissue infections;
– Bone and joint infections;
– Urinary tract infections (including pyelonephritis, urinary tract infections).Infections of the urinary tract (including pyelonephritis);
– Abdominal infections, inflammatory diseases of the gastrointestinal tract, biliary tract (including cholangitis, empyema, cholangitis), infections of the abdominal cavity and organs of internal medicine. Cholangitis, empyema of gall bladder;
– infections of the pelvic organs;
– peritonitis;
– sepsis;
– bacterial meningitis;
– bacterial endocarditis;
– acute and complicated gonorrhea;
– Lyme disease;
– shigellosis;
– salmonellosis.

Prevention and treatment of infectious postoperative complications.

Active ingredient

Composition

How to take, the dosage

Azaran is administered in m/m or intravenously.

In adults and children over 12 years of age the average daily dose is 1-2 g of ceftriaxone once daily.

The maximum daily dose for adults is 4 g.

In newborns (up to two weeks of age) the dose is 20-50 mg/kg/day. The maximum daily dose should not exceed 50 mg/kg.

For children aged 15 days to 12 years, the daily dose is 20-80 mg/kg.

Special Instructions

With caution Azaran is prescribed in non-specific ulcerative colitis, liver and kidney function disorders, enteritis and colitis associated with the use of antibacterial drugs.

The drug is used only in medical institutions.

In simultaneous severe renal and hepatic impairment, plasma ceftriaxone concentrations should be determined regularly in patients on hemodialysis.

When using Azaran it is impossible to drink alcohol because of possible disulfiram-like effects (redness of face, spastic abdominal and gastric pain, nausea, vomiting, headache, decreased blood pressure, tachycardia, shortness of breath).

Contraindications

Hypersensitivity to ceftriaxone and other cephalosporins, penicillins.

Side effects

Allergic reactions: urticaria, fever, chills, eosinophilia, rash, itching, exanthema, allergic dermatitis, erythema exudative multiforme, edema, anaphylactic shock, serum sickness, abdominal pain, bronchospasm.

CNS disorders: headache, dizziness.

Digestive system disorders: nausea, vomiting, impaired taste, flatulence, stomatitis, glossitis, diarrhea, pseudomembranous enterocolitis, pseudocholithiasis, dysbacteriosis, increased activity of liver transaminases and ALP, hyperbilirubinemia.

Urinary system disorders: oliguria, hypercreatininemia, increased urea, glucosuria, hematuria.

Hematopoietic system disorders: anemia, leukopenia, leukocytosis, lymphopenia, neutropenia, granulocytopenia, thrombocytopenia, thrombocytosis, basophilia.

With the coagulation system: nasal bleeding, hemolytic anemia, increased (decreased) prothrombin time.

Local reactions: when administered intravenously – phlebitis, soreness along the vein; when administered intravenously – soreness at the injection site.

Other: superinfection (including candidiasis).

Pregnancy use

The use of Azaran in pregnancy is possible only in cases when the estimated benefit to the mother exceeds the potential risk to the fetus (ceftriaxone penetrates the placental barrier).

If it is necessary to use Azaran during lactation, the question of stopping breastfeeding should be decided (ceftriaxone is excreted with breast milk).

Similarities